Apigenin 7-Glucuronide is a metabolite of Apigenin, which induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation. Apigenin has also been reported to enhance the gap juntion intracellular communication in liver cells.
ChEBI: Apigenin 7-glucuronide is a member of flavonoids and a glucosiduronic acid.
NO | PGE | TNF-α | NOS | COX | AP-1 | ERK | p38MAPK | MMP-3 | MMP-8 | MMP-9 | MMP-13
MMP-3: 12.87 μM (IC50); MMP-8: 22.39 μM (IC50); MMP-9: 17.52 μM (IC50); MMP13: 0.27 μM (IC50)
