Orange-yellow crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from tomato rhizomes, leaves, green fruits, high in content, and low in mature fruits.
Columbamine has antibacterial, anti-inflammatory, antihistamine, cardiotonic, anticancer effects.
ChEBI: Columbamine is a berberine alkaloid and an organic heterotetracyclic compound.
Columbamine is a quaternary isoquinoline alkaloid extracted from plants.
Columbamine (5-20 mg/kg; 23 days) significantly decreases the tumor volumes in a dose-dependent manner in HCT116 xenograft mice model[4].
| Animal Model: | Six-weeks-old male BALB/c nude mice (subcutaneously injected with HCT116 and control cells on the opposite flanks of the same mouse)[4] |
| Dosage: | 5, 10, 20 mg/kg |
| Administration: | Administered to experimental mice for 23 days |
| Result: | Decreased the tumor volumes in a dose-dependent manner. |
