Chemical Properties
Orange-yellow crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from tomato rhizomes, leaves, green fruits, high in content, and low in mature fruits.
Uses
Columbamine has antibacterial, anti-inflammatory, antihistamine, cardiotonic, anticancer effects.
Definition
ChEBI: Columbamine is a berberine alkaloid and an organic heterotetracyclic compound.
Biological Activity
Columbamine is a quaternary isoquinoline alkaloid extracted from plants.
in vivo
Columbamine (5-20 mg/kg; 23 days) significantly decreases the tumor volumes in a dose-dependent manner in HCT116 xenograft mice model[4].
| Animal Model: | Six-weeks-old male BALB/c nude mice (subcutaneously injected with HCT116 and control cells on the opposite flanks of the same mouse)[4] |
| Dosage: | 5, 10, 20 mg/kg |
| Administration: | Administered to experimental mice for 23 days |
| Result: | Decreased the tumor volumes in a dose-dependent manner. |
IC 50
CYP3A4: 30.6 μM (IC
50)
