4-Methoxycyclohexanol

150-76-5

18068-06-9

The general procedure for the synthesis of p-methoxycyclohexanol from p-hydroxyanisole was as follows: 400 g of 4-methoxyphenol was dissolved in 450 mL of methanol and 40 g of 5 wt% palladium-carbon catalyst was added. The reaction system was pressurized to 7 MPa under hydrogen atmosphere and stirred at 140 °C for 5 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was subjected to distillation under reduced pressure to recover the solvent. The final p-methoxycyclohexanol was obtained with a purity of about 97% and a yield of 98.5%.