牛心果鹼
牛心果鹼 性质
| 熔点 | 125-126°C |
|---|---|
| 沸点 | 648.96°C (rough estimate) |
| 密度 | 1.4371 (rough estimate) |
| 折射率 | 1.6800 (estimate) |
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.95±0.10(Predicted) |
| 颜色 | 米白色至黄色 |
| 旋光性 (optical activity) | +88.318 (c 0.21, ethanol) |
牛心果鹼 用途与合成方法
|
JAK2
|
STAT3
|
NF-κB
|
Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) inhibits in a concentration-dependent manner the contractions induced by Phenylephrine (1 μM), KCl (80 mM) and KCl (30 mM), (IC
50
=40±10, 240±40 and 300±40 μM, respectively) in isolated rat aortic rings with intact endothelium.
Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) antagonizes CaCl
2
-induced contractions, and also inhibits the intracellular calcium dependent transient contractions induced by Norepinephrine (1μM), but not those induced by Caffeine (20 mM).
Reticuline (5, 10 and 20 mg/kg, i. v., randomly) injections produced an intense hypotension in normotensive rats. The hypotensive effect of Reticuline is probably due to a peripheral vasodilation in consequence of: 1) muscarinic stimulation and NOS activation in the vascular endothelium, 2) voltage-dependent Ca 2+ channel blockade and/or 3) inhibition of Ca 2+ release from norepinephrine-sensitive intracellular stores.
牛心果鹼 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-N1356 | 牛心果鹼 | 485-19-8 | 1mg | 2000 |
| 2024-11-08 | HY-N1356 | 牛心果鹼 | 485-19-8 | 5mg | 4600 |
