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Isoconazole

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Isoconazole Basic information
Isoconazole Chemical Properties
  • Boiling point:555.1±50.0 °C(Predicted)
  • Density 1.40±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility Practically insoluble in water, very soluble in methanol, freely soluble in ethanol (96 per cent).
  • pka6?+-.0.12(Predicted)
  • form neat
  • CAS DataBase Reference27523-40-6
Isoconazole Usage And Synthesis
  • Chemical PropertiesWhite or almost white powder.
  • OriginatorFazol,Fournier,France,1979
  • UsesAntibacterial; antifungal.
  • Manufacturing ProcessTo a stirred and refluxing solution of 40 parts of benzene and 35 parts of dimethylformamide (both solvents previously dried azeotropically) are added successively 1.6 parts of sodium hydride and 7.7 parts of α-(2,4- dichlorophenyl)imidazole-1-ethanol, (cooling on ice is necessary). After the addition is complete, stirring and refluxing is continued for 30 minutes. Then there are added 7.8 parts of 2.6-dichlorobenzyl chloride and the whole is stirred at reflux for another 3 hours. The reaction mixture is poured onto water and the product 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl] imidazole, is extracted with benzene. The extract is washed twice with water, dried, filtered and evaporated in vacuo. The base residue is dissolved in a mixture of acetone and diisopropyl ether and to this solution is added an excess of concentrated nitric acid solution. The precipitated nitrate salt is filtered off and recrystallized from a mixture of methanol and diisopropyl ether, yielding 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl]imidazole nitrate; melting point 179°C.
  • Therapeutic FunctionAntibacterial, Antifungal
Isoconazole(27523-40-6)Related Product Information
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