clear yellow to yellow-green liquid
Used in synthetic applications of carbon-substituted iminium salts
Reactant for:
Synthesis of mutasynthons added to cultures of A. pretiosum for mutasynthetic generation of ansamitocin derivatives
Oxalic acid formation from hydroxyl radical substitutions
Cyclization to produce CRF1 receptor antagonists
Preparation, optical and electrochemical studies of thiophene end capped olig(2,3-alkylthieno[3,4-b]pyrazine)
Asymmetrical synthesis of glycosyl chlorides and bromides
Leptin from rat has been used:
- to check the effect of intranasal nerve growth factor (NGF) on NGF activity in the spinal cord of Sprague-Dawley rats
- for validation of labelling for leptin-bearing cells of Sprague-Dawley rats
- to study the effect of leptin on STAT3 (signal transducer and activator of transcription 3) phosphorylation in neural population of Sprague-Dawley rats
- to study leptin response towards chemoreflex in nucleus of the solitary tract
- in rats, to check the effect of association between leptin and neuronal nitric oxide pathway on penicillin-induced epileptiform activity
Leptin is a hormone produced primarily in adipocytes, although leptin mRNA has also been identified in placenta and fetal tissues, gastric tissue and liver. Its primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight. Leptin increases the production of nitric oxide in endothelial cells and stimulates angiogenesis in vitro and in vivo.Human and mouse leptin share ~84% sequence identity.
