Xylometazoline (1 mg/mL, intranasal, single dose) improves sinusitis in rats[3].
Xylometazoline and its excipients, when used for prolonged periods, may cause ophthalmic problems such as dry eyes, corneal edema, cataracts, retinal nerve fiber layer damage, and vascular damage[4].
| Animal Model: | SpragueDawley rat induced by platelet-activating factor[3] |
| Dosage: | 1 mg/mL; single dose |
| Administration: | Intranasal administration |
| Result: | Showed almost no vascular congestion, little infiltration, and the epithelium was completely intact. |
