3-Trifluoromethylpyridine

Use copper iodide (I) (13.3 mg, 0.07 mmol), 1,10-phenanthroline (12.6 mg, 0.07 mmol), KF (61 mg, 1.05 mmol, 3 eq.), and aryl iodide (0.35 mmol, 1 eq.). Close the reaction vessel, then evacuate and refill three times with argon or nitrogen. Add DMSO (1.0 mL) and aryl iodide (0.35 mmol) (if it is not solid), B(OMe)3 (109 mg, 117 μL, 1.05 mmol, 3 eq.), and TMSCF3 (149.3 mg, 155 μL, 1.05 mmol, 3 eq.) via syringe.

(eq.). The solid aryl iodide was weighed directly in the reaction vessel. The resulting orange-yellow suspension was stirred at 60°C for 24 hours. The sample was dissolved in Et₂O and analyzed by GC-MS to obtain 3-trifluoromethylpyridine, yield: 100%.

Colorless liquid;Pale yellow liqui

3-(Trifluoromethyl)pyridine is a reagent used to improve amyloid detection in the brain during MRI.