White or almost white, hygroscopic, crystalline powder
Antihypertensor;Gonad stimuling agent
Clopamide is a thiazide-like diuretic that inhibits sodium/chloride cotransporters in the proximal convoluted tubule of the kidney, which prevents the reabsorption of sodium and chloride. This compound is intended for research purposes only.
Antihypertensive; diuretic.
ChEBI: 4-chloro-N-[(2S,6R)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide is a sulfonamide.
To a solution of 5.5 g of 3-chlorsulfonyl-4-chlorobenzoylchloride in 20 ml
chlorobenzole 3.3 g of 1-amino-cis-2,6-dimethylpiperidin-hydrochloride slowly
was added at room temperature. Reaction mixture was heated to 100°-105°C
during 8 h, then it was cooled to room temperature. The precipitated crystals
of N-[cis-2,6-dimethyl-piperidyl-(1)]-3-chlorsulfonyl-4-chlorobenzoylamide
were filtered and dried at 100°C under vacuo, then was treated by ammonium
at room temperature. The obtained product was chromatographed (aluminum
oxide; eluent: chloroform-methanol 9:1 and methanol-ether) to give N-[cis-
2,6-dimethylpiperidyl-(1)]-3-sulfamyl-4-chlorbenzoylamide, melting point
235°-237°C.
Diuretic, Antihypertensive
