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BUTYRONITRILE

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BUTYRONITRILE Basic information
BUTYRONITRILE Chemical Properties
  • Melting point:−112 °C(lit.)
  • Boiling point:115-117 °C(lit.)
  • Density 0.794 g/mL at 25 °C(lit.)
  • vapor density 2.4 (vs air)
  • vapor pressure 23 mm Hg ( 25 °C)
  • refractive index n20/D 1.384(lit.)
  • Flash point:62 °F
  • storage temp. Flammables area
  • solubility slightly soluble in water; soluble in alcohol, ether and dimethylformamide
  • form Liquid
  • color Clear
  • Water Solubility Miscible with benzene, alcohol, ether and dimethylformamide. Slightly soluble in water.
  • Merck 14,1597
  • BRN 1361452
  • Exposure limitsTLV-TWA 22.5 mg/m3 (8 ppm) (NIOSH).
  • Stability:Stable. Combustible. Substances to be avoided include strong acids, strong bases, strong oxidizing agents and strong reducing agents.
  • CAS DataBase Reference109-74-0(CAS DataBase Reference)
  • EPA Substance Registry SystemButanenitrile (109-74-0)
Safety Information
  • Hazard Codes T,F
  • Risk Statements 10-23/24/25-11
  • Safety Statements 45-63-36/37-16
  • RIDADR UN 2411 3/PG 2
  • WGK Germany 1
  • RTECS ET8750000
  • Autoignition Temperature910 °F
  • Hazard Note Toxic
  • TSCA Yes
  • HazardClass 3
  • PackingGroup II
  • HS Code 29269095
  • ToxicityLD50 orally in rats: 0.14 g/kg (Smyth)
MSDS
BUTYRONITRILE Usage And Synthesis
  • Chemical Propertiescolourless liquid
  • Chemical Propertiesn-Butyronitrile has a sharp suffocating odor. Forms cyanide in the body.
  • UsesButyronitrile is used as a chemical intermediate.
  • UsesBasic material in industrial, chemical, and pharmaceutical intermediates and products; poul- try medicines.
  • DefinitionChEBI: A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a propyl group.
  • Production Methodsn-Butyronitrile is prepared from 1-butanol by controlled cyanation with NH3 at 300°C in the presence of Ni-Al203 or zinc phosphide catalysts.
  • General DescriptionA clear colorless liquid. Flash point 76°F. Less dense than water. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used in the manufacture of other chemicals.
  • Air & Water ReactionsHighly flammable. Slightly soluble in water.
  • Reactivity ProfileBUTYRONITRILE can react vigorously with oxidizing reagents, when heated to decomposition, BUTYRONITRILE emits highly toxic fumes of cyanides and oxides of nitrogen [Sax, 9th ed., 1996, p. 609]. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.
  • HazardFlammable, dangerous fire risk.
  • Health HazardDizziness, rapid respirations, headache, drowsiness, drop in blood pressure and pulse, delayed symptoms. May cause cyanosis (blue-grey coloring of skin and lips due to lack of oxygen)
  • Health Hazardn-Butyronitrile is considered a highly hazardous material and full precautions should be used to prevent skin contact or inhalation of the vapor. Inhaled n-butyronitrile is about 2.4 times as toxic as acetonitrile. In order to protect workers, the recommended TWA limit is obtained by dividing that for acetonitrile by the factor 2.4. NIOSH has therefore recommended that employee exposure should not exceed 8 ppm (v/v) (22 mg/m3) compound as a TLV-TWA.
  • Health HazardButyronitrile showed moderate to high toxicity on test animals. It is an acute toxicant by all routes: inhalation, ingestion, and absorption through skin. The target organs are the liver, kidney, central nervous system, lungs, and sense organs, as well as the peripheral nerve. Its toxicity is on the same order as that of propionitrile; its inhalation toxicity is slightly lower than that of propionitrile, and its oral toxicity is slightly greater than that of propionitrile.
    Inhalation can cause nausea, respiratory distress, and damage to liver. Willhite (1981) reported a LC50 value of 249 ppm in mice from 1 hour exposure to its vapor. It produced ataxia, dyspnea, and corneal damage in test animals when given intraperitoneally. The toxic symptoms from subcutaneous applications are tremor, dyspnea, respiratory depression, and spastic paralysis. It is toxic only at low levels by skin absorption.
    LD50 value, oral (mice): 27.7 mg/kg
    There is no report on its teratogenicity. The reproductive effect of this compound is expected to be similar to that of propionitrile.
  • Fire HazardSpecial Hazards of Combustion Products: Toxic cyanide fumes
  • Industrial usesn-Butyronitrile is used as an industrial solvent, an intermediate in the chemical industry and in poultry medicines.
  • Safety ProfileA poison by ingestion, skin contact, intraperitoneal, and subcutaneous routes. Moderately toxic by inhalation. Experimental reproductive data. A skin irritant. Dangerous fire hazard when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx and CN-.
  • Purification MethodsTreat it with conc HCl until the smell of the isonitrile had gone, then dry with K2CO3 and fractionally distil [Turner J Chem Soc 1681 1956]. Alternatively it is twice heated at 75o and stirred for several hours with a mixture of 7.7g Na2CO3 and 11.5g KMnO4 per L of butyronitrile. The mixture is cooled, then distilled. The middle fraction is dried over activated alumina. [Schoeller & Wiemann J Am Chem Soc 108 22 1986, Beilstein 2 IV 806.]
  • Waste DisposalBurning in a chemical incinerator equipped with an afterburner and scrubber is the most effective way to destroy the compound. Oxidation with ethanolic–KOH can convert butyronitrile to nonhazardous cyanate.
BUTYRONITRILE Preparation Products And Raw materials
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