ChemicalBook Product Catalog Biochemical Engineering Plant extracts Sanggenon C

Sanggenon C

Product NameSanggenon C
CAS80651-76-9
MFC40H36O12
MW708.71
EINECS
MOL File80651-76-9.mol

Chemical Properties

Melting point	> 240°C (dec.)
Boiling point	995.5±65.0 °C(Predicted)
Density	1.512
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	Acetone (Slightly), Methanol (Slightly)
pka	6.61±0.60(Predicted)
form	Solid
color	Yellow
InChIKey	XETHJOZXBVWLLM-HUKCQOFTSA-N
SMILES	[C@@]12(C/C=C(/C)\C)C3=CC=C(O)C=C3O[C@]1(O)C(=O)C1=C(O)C([C@@H]3[C@H](C(=O)C4=CC=C(O)C=C4O)[C@@H](C4=CC=C(O)C=C4O)CC(C)=C3)=C(O)C=C1O2

Usage And Synthesis

Description

Sanggenone C is a flavonoid that has been found in mulberry bark and has diverse biological activities. It inhibits TNF-α- or IL-1β-induced polymorphonuclear leukocyte (PMN) adhesion to human synovial cells (HSCs; IC₅₀s = 27.29 and 54.43 nM, respectively), as well as inhibits NF-κB activation in HSCs. Sanggenone C induces apoptosis and production of reactive oxygen species (ROS) in HT-29 cells when used at concentrations ranging from 10 to 40 μM. It decreases cell viability of HT-29 cells in vitro and reduces tumor growth in an HT-29 mouse xenograft model when administered at a dose of 10 mg/kg. Sanggenone C increases vertebrate column bone mineralization in a zebrafish model of prednisone-induced osteoporosis. It also attenuates cardiac hypertrophy and fibrosis and reduces activation of nuclear factor of activated T cells 2 (NFAT2) in a mouse model of pressure overload-induced cardiac hypertrophy.

Chemical Properties

Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Morus alba bark.

Uses

Sanggenone C is a flavanone isolated from Morus plant that showed cytotoxicity against human oral tumor cell lines (HSC-2 and HSG). Sanggenone C is also an inhibitor of protein tyrosine phosphatase 1B.

Definition

ChEBI: Sanggenon C is a diarylheptanoid.

in vivo

Sanggenon C (10, 20 mg/kg/day; Intraperitoneally; for 3 weeks) improves impaired cardiac function following aortic banding (AB). Sanggenon C protects against cardiac hypertrophy^[1].
Sanggenon C (10, 20 mg/kg/day; Intraperitoneally; for 21 days) suppresses the tumor burden in the nude mice bearing tumor xenografts derived from AGS. Sanggenon C downregulates levels of p-ERK expression^[2].

Animal Model:	Male C57/BL6 mice (weight 23.5-27.5 g; age, 8 weeks)^[1]
Dosage:	10, 20 mg/kg
Administration:	Intraperitoneally; daily; for 3 weeks
Result:	Prevented the development of ventricular dysfunction, as evidenced by decreased LV end-diastolic diameter, LV end-systolic diameter, and increased LVFS and LVEF.

target

NF-kB | NO | NOS | IkB | IKK

IC 50

NF-κB; ERK

References

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] LI-DONG CHEN. Sanggenon C induces apoptosis of colon cancer cells via inhibition of NO production, iNOS expression and ROS activation of the mitochondrial pathway.[J]. Oncology reports, 2017: 2123-2131. DOI: 10.3892/or.2017.5912
[3] HUIJUAN WANG. Sanggenon C Stimulates Osteoblastic Proliferation and Differentiation, Inhibits Osteoclastic Resorption, and Ameliorates Prednisone-Induced Osteoporosis in Zebrafish Model.[J]. Molecules, 2018. DOI: 10.3390/molecules23092343
[4] LILI XIAO. Sanggenon C protects against pressure overloadinduced cardiac hypertrophy via the calcineurin/NFAT2 pathway.[J]. Molecular medicine reports, 2017: 5338-5346. DOI: 10.3892/mmr.2017.7288

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