Cephalomannine (0.4 mg/kg, intraperitoneal injection, 10 days) could significantly inhibit the growth of lung cancer cells in nude mice xenograft model, with no obvious side effects[3].
Cephalomannine can interrupt the interaction between APEX1 and HIF-1α by competitive binding with APEX1[3].
| Animal Model: | BALB/C nude mice xenograft model[3] |
| Dosage: | 0.4 mg/kg |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Reduced the volume and weight of H460 xenograft tumors. |
| Animal Model: | BALB/c nude mice bone metastasis xenograft model[4] |
| Dosage: | 10 mg/kg, 20 mg/kg |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Decreased bone destruction, reduced bioluminescence intensity and number of bone metastases, significantly extended time to endpoint events, decreased UBE2S expression and number of osteoclasts, and did not produce significant toxicity to the heart, liver, or kidney of nude mice. |
