Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as hypoxic/ischemic brain injury, inflammatory bowel disease and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects). Recent reports indicate that GGA protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression. Other studies have shown that GGA "can induce expression of HSPB8 and HSPB1 as well as reduce the formation of amyloid oligomers and insoluble aggregates in HSPB5 R120G TG mice."
