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Teprenone

$ 1.00 /1KG

Min. Order1KG
Purity95%~99%
Cas No6809-52-5
Supply Ability1ton
Update time2019-12-20

career henan chemical co

5YR

China

Chemical Properties

Product Name	Teprenone
CAS No	6809-52-5
EC-No	200-110-4
Min. Order	1KG
Purity	95%~99%
Supply Ability	1ton
Release date	2019/12/20

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Teprenone Basic information

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Product Name:

Teprenone

Synonyms:

All trans-Teprenone;6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one, mixture of (5E,9E,13E) and (5Z,9E,13E) isomers;6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraen-2-one;UNII-S8S8451A4O;Teprenone, >=98%;Teprenone (trans,trans);TEPRENONE;13,17-nonadecatetraen-2-one,6,10,14,18-tetramethyl-9

CAS:

6809-52-5

MF:

C46H76O2

MW:

661.09

EINECS:

614-276-0

Product Categories:

Aliphatics;Intermediates & Fine Chemicals;Pharmaceuticals

Mol File:

6809-52-5.mol

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Teprenone Chemical Properties

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Boiling point

bp0.01 155-160°

density

d420.5 0.9081

refractive index

nD20 1.4947

storage temp.

?20°C

solubility

DMSO: >5mg/mL

form

liquid

color

clear

Merck

14,9228

InChIKey

SBOCYPUKNYDTSX-DMLVRTFPSA-N

CAS DataBase Reference

6809-52-5(CAS DataBase Reference)

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Safety Information

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WGK Germany

RTECS

RA5391300

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MSDS Information

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Teprenone Usage And Synthesis

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Description

Teprenone (geranylgeranylacetone) is an antiulcer agent whose synthesis was inspired by the gastric protecting properties of Coenzyme Q10. Teprenone is reported to act via enhancement of gastric mucosal glycoprotein secretion.

Chemical Properties

Yellow Oil

Originator

Eisai (Japan)

Uses

An anti-ulcerative. Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects). Reports indicate that GGA protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression. Other studies have shown that GGA induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice.

Definition

ChEBI: A terpene ketone in which a (9E,13E)-geranylgernayl group is bonded to one of the alpha-methyls of acetone (it is a mixture of 5E- and 5Z-geoisomers in a 3:2 ratio).

Brand name

SELBEX

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