4,4?-Difluorobenzil is used in the preparation of 2,3-bis(4-fluorophenyl)thieno[3,4-b]pyrazine. It is also used in the synthesis of poly(ether-α-diketone)s, via nucleophilic substitution reaction with bisphenol A, 4,4?-difluoro-2,3-diphenylpyrazine (DPPF) and 4,4?-difluoro-5-methyl 2,3-diphenylpyrazine (MDPPF), via direct condensation with ethylenediamine and 1,2-diaminopropane, respectively, 2,3-bis(4-fluorophenyl)quinoxaline, via direct condensation with 1,2-phenylenediamine.