H372：Causes damage to organs through prolonged or repeated exposure
Precautionary statements
P260：Do not breathe dust/fume/gas/mist/vapours/spray.
P270：Do not eat, drink or smoke when using this product.
P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P314：Get medical advice/attention if you feel unwell.
P330：Rinse mouth.
P403：Store in a well-ventilated place.
Description
Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38, Cat.# 10-2425), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3
