Cisplatin is a platinum-containing compound that acts as an alkylating agent, interacting with DNA to form adducts which interfere with replication and transcription, culminating in apoptosis. It is used, alone or in combination therapy, in the treatment of several types of cancer, including testicular, ovarian, cervical, bladder, and lung cancers. Cisplatin also inhibits the RecA recombinase of M. tuberculosis (IC50 = 2 μM), blocking protein splicing and cell growth.
