플루옥시메스테론

한글명:플루옥시메스테론

카스 번호76-43-7

상품명:Fluoxymesterone

CBNumberCB9258118

분자식C20H29FO3

포뮬러 무게336.44

MOL 파일76-43-7.mol

동의어(한글)

플루옥시메스테론

화학적 성질

녹는점	240 °C
알파	104 º (c=1,EtOH)
끓는 점	474.2±45.0 °C(Predicted)
밀도	1.0455 (estimate)
저장 조건	-20°C
용해도	H₂O: ≤0.5 mg/mL
물리적 상태	고체(감광성)
산도 계수 (pKa)	13.40±0.70(Predicted)
색상	하얀색
수용성	무시할 만한
Merck	13,4212
InChI	InChI=1/C20H29FO3/c1-17-8-6-13(22)10-12(17)4-5-15-14-7-9-19(3,24)18(14,2)11-16(23)20(15,17)21/h10,14-16,23-24H,4-9,11H2,1-3H3/t14-,15-,16-,17-,18-,19-,20-/s3
InChIKey	YLRFCQOZQXIBAB-MGWAJYFFNA-N
SMILES	[C@]12(F)[C@@H](O)C[C@]3(C)[C@](CC[C@@]3([H])[C@]1([H])CCC1=CC(=O)CC[C@]21C)(O)C \|&1:0,2,5,7,10,12,22,r\|
CAS 데이터베이스	76-43-7(CAS DataBase Reference)
NIST	4-Androsten-3-one, 9alpha-fluoro-11beta,17beta-dihydroxy-17alpha-methyl-,(76-43-7)
EPA	Fluoxymesterone (76-43-7)

위험 및 안전 성명

위험품 표기	Xn,T,F
위험 카페고리 넘버	63-38-19-11-61-60
안전지침서	22-36-24/25-45-53
WGK 독일	3
RTECS 번호	BV8390000
HS 번호	29372900
유해 물질 데이터	76-43-7(Hazardous Substances Data)
독성	LD50 intraperitoneal in mouse: 2350mg/kg

그림문자(GHS)

플루옥시메스테론 MSDS

플루옥시메스테론 화학적 특성, 용도, 생산

개요
Fluoxymesterone(Halotestin) is a steroid with an androgenic property that is used in primary hypogonadism and testicular failure due to cryptorchidism, vanishing testes syndrome, or orchidectomy; and in hypogonadotrophic hypogonadism and luteinizing hormone-releasing hormone (LHRH) deficiency or pituitary hypothalamic injury from tumors, trauma, or radiation. It mimics the actions of testosterone, which is responsible for normal growth and development of the male sex organs and for the maintenance of secondary sex characteristics. In female postmenopausal patients, fluoxymesterone may be indicated in the palliation of recurrent mammary cancer.
화학적 성질
white to light yellow crystal powder
용도
Fluoxymesterone is an anabolic steroid with androgenic activity. It is used in the treatment of male hypogonadism. It showed antitumor effects on pregnancy-dependent mammary tumors TPDMT-4.
Indications
Fluoxymesterone promotes growth and development of male reproductive organs, maintains secondary sex characteristics, increases protein anabolism, and decreases protein catabolism. It is used to treat symptoms of low testosterone in adult men who have hypogonadism (a condition in which the body does not produce enough natural testosterone). It is also used for palliation of androgen-responsive recurrent mammary cancer in women who are more than 1 year but less than 5 years postmenopausal (women).
정의
ChEBI: Fluoxymesterone is an anabolic androgenic steroid, a 17beta-hydroxy steroid, an 11beta-hydroxy steroid, a fluorinated steroid and a 3-oxo-Delta(4) steroid. It has a role as an antineoplastic agent and an anabolic agent.
일반 설명
Fluoxymesterone, 9α-fluoro-11β,17β-dihydroxy-17-methylandrost-4-en-3-one, is ahighly potent, orally active androgen, about 5 to 10 timesmore potent than testosterone. It can be used for all theindications discussed previously, but its great androgenicactivity has made it useful primarily for treatment of theandrogen-deficient male.
Pharmacokinetics
By substituting a 9α-fluoro group onto an analog of 17α-methyltestosterone, fluoxymesterone has 20 times the anabolic and 10 times the androgenic activity of 17α-methyltestosterone. It has a mean half-life of 9 hours, and less than 5% of the drug is excreted unchanged. An adverse effect of fluoxymesterone is sodium and water retention that could lead to edema.
Safety Profile
Fluoxymesterone is contraindicated in male subjects with known or suspected carcinoma of the prostate gland. Prolonged use of high-dosage 17-alpha-alkyl androgens is known to have caused hypercalcemia, hepatic adenoma, hepatocellular carcinoma, and hepatitis. Fluoxymesterone, which accelerates bone maturation without producing linear growth, should be used cautiously in males with delayed puberty. Edema and CHF may occur in patients with preexisting cardiovascular problems. Androgens cause virilization in female subjects.

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