벤질

한글명:벤질

카스 번호134-81-6

상품명:Benzil

CBNumberCB8478221

분자식C14H10O2

포뮬러 무게210.23

MOL 파일134-81-6.mol

동의어(한글)

벤질

디페닐에탄디온

화학적 성질

녹는점	94-95 °C(lit.)
끓는 점	346 °C
밀도	1,521 g/cm³
증기압	1 mm Hg ( 128.4 °C)
굴절률	1.5681 (estimate)
인화점	346-348°C
저장 조건	Store below +30°C.
용해도	<0.5g/L
물리적 상태	결정성 분말
색상	하얀색
수용성	0.5g/L(20℃)
Merck	14,1078
BRN	608047
Dielectric constant	13.0（94℃）
안정성	안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다.
InChIKey	WURBFLDFSFBTLW-UHFFFAOYSA-N
CAS 데이터베이스	134-81-6(CAS DataBase Reference)
NIST	Ethanedione, diphenyl-(134-81-6)
EPA	Benzil (134-81-6)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36/37/38

안전지침서

26-36-37/39

WGK 독일

RTECS 번호

DD1925000

F 고인화성물질

위험 참고 사항

Irritant

TSCA

Yes

HS 번호

29143900

독성

LD50 orally in Rabbit: 2710 mg/kg

NFPA 704:

	1
2		0

그림문자(GHS)

벤질 MSDS

벤질 화학적 특성, 용도, 생산

화학적 성질
yellow crystals or powder
용도
Benzil is used as a pharmaceutical intermediate and uv curing resin photosensitizer. In polymer chemistry, it is used as a photoinitiator. Further, it serves as a potent inhibitor of human carboxylesterases. It is used in the preparation of diketimines by reacting with amines. It is also involved in the famous benil-benzilic acid rearrangement. In addition this, it reacts with 1,3-diphenylacetone to get tetraphenylcyclopentadienone.
화학 반응
A reaction in which benzil (1,2- diphenylethan-1,2-dione) is treated with hydroxide and then with acid to give benzilic acid (2-hydroxy-2,2-diphenylethanoic acid):
C₆H₅.CO.CO.C₆H₅→
(C₆H₅)₂C(OH).COOH
The reaction, which involves migration of a phenyl group (C₆H₅-) from one carbon atom to another, was the first rearrangement reaction to be described (by Justus von Liebig in 1828).
benefits
Benzil has potential applications in biological metabolism and clinical medicine. Benzil derivates exhibit radical scavenging and antibacterial and hypertensive, antiprotozoal, antiproliferative, and antimitotic activities. Benzil derivatives have versatile applications in the pharmaceutical industry, and various heterocyclic compounds such as triazine, quinoxaline, and imidazole can be synthesized from 1,2-diketones. It is also used as a nanocatalyst in the application of imidazole derivatives. Recently, it is reported that benzil derivatives acted as photosensitive agents and photoinitiators due to its antitumor activity[1].
Safety
Potential Acute Health Effects: Very hazardous in case of skin contact (irritant), of eye contact (irritant). Hazardous in case of ingestion, of inhalation.
The substance is toxic to lungs, mucous membranes. Repeated or prolonged exposure to the substance can produce target organs damage. Eye Contact: Check for and remove any contact lenses.
Fine dust dispersed in air may ignite. Dust can form an explosive mixture in air. Thermal decomposition can lead to release of irritating gases and vapors. Keep product and empty container away from heat and sources of ignition.
Safety Profile
Low toxicity by ingestion. An eyeirritant. Combustible. When heated to decomposition itemits acrid smoke and irritating fumes.
Purification Methods
Crystallise benzil from *benzene after washing with alkali. (Crystallisation from EtOH did not free benzil from material reacting with alkali.) [Hine & Howarth J Am Chem Soc 80 2274 1958.] It has also been crystallised from CCl4, diethyl ether or EtOH [Inoue et al. J Chem Soc, Faraday Trans 1 82 523 1986]. [Beilstein 7 IV 2502.]

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