카르브아밀메틸콜린 염화물

한글명:카르브아밀메틸콜린 염화물

카스 번호590-63-6

상품명:Bethanechol

CBNumberCB8156880

분자식C7H17ClN2O2

포뮬러 무게196.68

MOL 파일590-63-6.mol

동의어(한글)

카르브아밀메틸콜린염화물

카르브아밀메틸콜린염화물(CARBAMYLMETHYLCHOLINECHLORIDE)

화학적 성질

녹는점	187-190°C
저장 조건	Inert atmosphere,2-8°C
용해도	H₂O: 1.7 g/mL는 4°C에서 며칠 동안 안정적입니다.
물리적 상태	수정 같은
색상	하얀색
수용성	H2O: 1.7g/mL (stable for several days at 4°C.) ethanol: 80mg/mL (stable for several days at 4°C.)
Merck	14,1185
CAS 데이터베이스	590-63-6(CAS DataBase Reference)
EPA	1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride (590-63-6)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

안전지침서

WGK 독일

RTECS 번호

BR5425000

TSCA

Yes

HS 번호

2924190002

NFPA 704:

	0
2		0

그림문자(GHS)

카르브아밀메틸콜린 염화물 화학적 특성, 용도, 생산

개요
Bethanechol is an agonist of muscarinic acetylcholine receptors with IC₅₀ values of 1,837, 25, 631, 317, and 393 μM for M_1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors. It inhibits M₂-mediated increases in cyclic AMP induced by isoproterenol in isolated guinea pig small intestine (IC₅₀ = 127 μM). Bethanechol increases basal tone of isolated porcine intravesical ureter (EC₅₀ = 4.27 μM). It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 μg/kg. Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract.
화학적 성질
White Solid
용도
cholinergic
정의
ChEBI: The chloride salt of bethanechol. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention.
일반 설명
Bethanechol, β-methylcholinechloride carbamate, (2-hydroxypropyl)trimethylammoniumchloride carbamate, carbamylmethylcholinechloride (Urecholine), is nonspecific in its action on muscarinicreceptor subtypes but appears to be more effective ateliciting pharmacological action of M3 receptors. It haspharmacological properties similar to those of methacholine.Both are esters of β-methylcholine and have feeblenicotinic activity. Bethanechol is inactivated more slowlyby AChE in vivo than is methacholine. It is a carbamyl esterand is expected to have stability in aqueous solutions similarto that of carbachol.
위험도
Headache, flushing, gastrointestinal distress, diarrhea, hypotension, excessive salivation, sweating, hypersensitivity.
Mechanism of action
Bentanechol is a drug, which has structurally unique qualities of both methacholine and carbachol, i.e. it contains both β-methyl and carbamate functional groups, and quite logically exhibits pharmacological properties of both the drugs. It is resistant to hydrolysis by cholinesterases and has a very minor effect on nicotinic receptors of the autonomic ganglia and neuromuscular junctions. Betanechol has more of a selective action on muscarinic receptors of the gastrointestinal tract and the bladder than do other cholinic esters.
Clinical Use
The main use of bethanechol chloride is in the relief ofurinary retention and abdominal distention after surgery.The drug is used orally and by subcutaneous injection. Itmust never be administered by intramuscular or intravenousinjection because of the danger from cholinergic overstimulationand loss of selective action. Proper administration ofthe drug is associated with low toxicity and no serious sideeffects. Bethanechol chloride should be used with caution inasthmatic patients; when used for glaucoma, it producesfrontal headaches from the constriction of the sphinctermuscle in the eye and from ciliary muscle spasms. Its durationof action is 1 hour.

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