과산화 벤조일

한글명:과산화 벤조일

카스 번호94-36-0

상품명:Benzoyl peroxide

CBNumberCB0484149

분자식C14H10O4

포뮬러 무게242.23

MOL 파일94-36-0.mol

동의어(한글)

과산화벤조일

벤조일퍼옥사이드

벤조일 퍼옥사이드

화학적 성질

녹는점	105 °C(lit.)
끓는 점	176°F
밀도	1.16 g/mL at 25 °C(lit.)
증기압	0.009Pa at 25℃
굴절률	1.5430 (estimate)
인화점	>230 °F
저장 조건	2-8°C
용해도	0.35mg/L
물리적 상태	가루
색상	하얀색
냄새	냄새 없는
수용성	불용성
Merck	14,1116
BRN	984320
노출 한도	TLV-TWA 5 mg/m³; IDLH 7000 mg/m³.
안정성	강한 산화제. 가연성이 높습니다. 갈거나 충격이나 마찰을 가하지 마십시오. 환원제, 산, 염기, 알코올, 금속, 유기 물질과 호환되지 않습니다. 가연성 물질과의 접촉, 가열 또는 마찰로 인해 화재나 폭발이 발생할 수 있습니다.
InChIKey	OMPJBNCRMGITSC-UHFFFAOYSA-N
LogP	3.2 at 20℃
CAS 데이터베이스	94-36-0(CAS DataBase Reference)
IARC	3 (Vol. 36, Sup 7, 71) 1999
NIST	Benzoyl peroxide(94-36-0)
EPA	Benzoyl peroxide (94-36-0)

위험 및 안전 성명

위험품 표기

O,Xn,N,Xi,E,T

위험 카페고리 넘버

8-36/37/38-43-36-2-7-1-51/53-21/22-62-50-61-3-39/23/24/25-40

안전지침서

53-17-26-36/37-45-60-36/37/39-3/7-14A-14-47-35-7-61-37/39-24

유엔번호(UN No.)

UN 3108 5.2

WGK 독일

RTECS 번호

DM8575000

자연 발화 온도

176 °F

TSCA

Yes

위험 등급

5.2

포장분류

HS 번호

29163200

유해 물질 데이터

94-36-0(Hazardous Substances Data)

독성

LD50 orally in Rabbit: 7710 mg/kg

IDLA

1,500 mg/m3

NFPA 704:

	4
1		4
	OX

그림문자(GHS)

과산화 벤조일 MSDS

과산화 벤조일 화학적 특성, 용도, 생산

순도시험

(1) 분말도 : 이 품목 5g을 건조한 53μ의 표준망체에 넣어 2분간 강하게 상하좌우로 흔들고 때때로 받는 그릇의 밑을 두들긴다. 다음에 1분간 방치하여 미분말을 침착시킨 다음 체 위의 잔류물을 평량할 때, 1g 이하이어야 한다.
  (2) 연소상태 : 이 품목 1g을 유리판 위에 놓고 높이 3mm, 폭 10mm로 하여 한쪽 끝에 점화할 때, 다른 한쪽 끝까지 연소하여서는 아니 된다.
  (3) 염산불용물 : 이 품목 0.2g에 묽은염산 10mL를 가하여 잘 흔들어 섞고 천천히 가열하여 약 1분간 끓이고 식힌 다음 에테르 약 8mL를 가하여 잘 흔들어 섞고 방치할 때, 양 액층은 어느 쪽이나 징명하여야 한다. 또 그 접계면에 뚜렷한 부유물이 있어서는 아니 된다.
  (4) 액성 : 이 품목 3g에 물 30mL를 가하고 3분간 흔들어 섞은 다음 여과하여 측정할 때, 이 액의 pH는 6.0～9.0이어야 한다.
  (5) 암모늄염 : 이 품목 0.2g에 수산화나트륨용액(2→5) 3mL를 가하여 끓일 때, 발생하는 가스가 물에 적신 적색리트머스지를 청색으로 변화시켜서는 아니 된다.
  (6) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.
  (7) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.
  (8) 바륨 : 이 품목 2g에 묽은질산 15mL를 가하여 흔들어 섞은 다음 여과하여 물로 씻고 그 씻은 액을 여액에 합쳐 물을 가하여 40mL로 하고 암모니아시액으로 pH를 2.4～2.8로 한 다음 물을 가하여 50mL로 하고 묽은황산 1mL를 가하여 10분간 방치할 때, 탁하여서는 아니 된다.
확인시험

이 품목 0.2g을 시험관에 취하여 클로로포름 7mL를 가하여 잘 흔들어 섞은 다음 방치하면 시험관 밑에 백색의 불용물이 남는다. 다음에 4,4′-디아미노디페닐아민시액 2mL를 가하면 액 및 불용물은 청록색을 나타낸다.
정량법

이 품목 약 1g을 정밀히 달아 공전플라스크에 넣고, 클로로포름 및 메탄올의 같은 양의 혼액 50mL를 가하여 흔들어 섞은 다음 구연산메탄올용액(1→10) 0.5mL 및 요오드칼륨용액(1→2) 2mL를 가하여 곧 밀전하고 때때로 흔들어 섞으면서 어두운 곳에 20분간 방치하고 유리한 요오드를 0.1N 치오황산나트륨용액으로 적정한다. 따로 같은 방법으로 공시험을 한다.
0.1N 치오황산나트륨용액 1mL ＝ 12.11mg C₁₄H₁₀O₄
정의

이 품목은 과산화벤조일(C₁₄H₁₀O₄)을 명반, 인산의 칼슘염류, 황산칼슘, 탄산칼슘, 탄산마그네슘 및 전분 중 1종 또는 2종 이상을 희석한 것이다.
제품 특성
과산화 벤조일(Benzoyl Peroxide)은 공업적으로 중합개시제,경화제,표백제 등에 사용하며 강력한 산화제이다. 가열,마찰,충격 등에 의하여 폭발되며 스스로 분해 되기 쉽고, 금속재료를 부식시키며, 인체에 미치는 영향이 큰 유기 화합물이므로 그 취급에 각별한 주의를 필요로 한다.
적용 분야
중합개시제(발포성 폴리스티렌, 아크릴수지 등)
수지의 경화제
밀가루, 압맥 표백제
사용 방법
희 석 : 제품을 용도에 따라 적합한 용제에 녹여 사용한다. (용제 : MMA, SM 등)
투입방법 : 용제에 녹여 펌프로 소량씩 반응기에 투입한다.또는 반응기에서 용제에 직접 녹인 다음 중합 반응하는 방법도 있다.
투 입 량 : 발포성 폴리스티렌 수지 및 불포화 폴리에스테르수지 제조시 0.2 ~1.0%(EPS 대비) 사용 가능.
유의 사항
저장 : 어둡고 차가운 곳으로 직사광선을 피하고, 화기엄금 및 난방을 하여서는 안된다. 금속 조각, 강산, 아민, 환원제 등 다른 약품과 같은 장소에 두는 피하고, 저장장소는 방폭전자 기구를 사용하여야 한다.저장용기는 유리 및 폴리에틸렌은 사용 가능하고, 금속용기는 일체 사용 금지.
취급 : 기구나 용기는 다른 약품에 사용되는 것을 피하고, 이물질이 혼입되지 않도록 밀봉한다. 피부에 묻으면 피부를 상하게 하므로 접촉되지 않도록 취급하고 눈에 들어가지 않도록 주의하여야 한다.
개요
Benzoyl Peroxide may affect workers in the electronics and plastics (epoxy resins and catalysts) industries, electricians, ceramic workers, dentists and dental technicians, laboratory technicians and bakers. As it was contained in candles, it also induced contact dermatitis in a sacristan. However, some positive tests are of unknown occupational relevance.
화학적 성질
Benzoyl peroxide is an odorless, white, or colorless crystalline powder with a faint odor of benzaldehyde resulting from the interaction of benzoyl chloride and a cooled sodium peroxide solution. It is used in specified cheeses at 0.0002% of milk level. It is also used for the bleaching of flour, slowly decomposing to exert its full bleaching action, which results in whiter flour and bread. The major decomposition product of benzoyl peroxide in water was benzoic acid, but trace amounts of phenyl benzoate, phenol, and hydroxybenzoic acids were formed. When carbon-14 la- beled benzoyl peroxide was reacted with whey, the same compounds were produced.
용도
Benzoyl Peroxide is a widely used organic compound of the peroxide family. It is used as a source offree radicals in many organic syntheses andto initiate polymerizations of styrene, vinylchloride, vinyl acetate, and acrylics; to curethermoset polyester resins and silicone rubbers;in medicine for treating acne; and forbleaching vegetable oil, cheese, flour, and fats.
Indications
Benzoyl peroxide is a potent oxidizing agent that has both antimicrobial and comedolytic properties; its primary use is in treating acne vulgaris. It is converted in the skin to benzoic acid; clearance of absorbed drug is rapid, and no systemic toxicity has been observed. The major toxicities are irritation and contact allergy. Outgrowth of bacteria resistant to topical antibiotics used to treat acne can be reduced by the addition of benzoyl peroxide in combination products such as erythromycin (Benzamycin) and clindamycin (Benzaclin).
World Health Organization (WHO)
Benzoyl peroxide slowly releases oxygen and hence is bactericidal. It is also keratolytic, antiseborrheic and irritant. It is used in the treatment of acne. Benzoyl peroxide is listed in the WHO Model List of Essential Drugs.
일반 설명
Benzoyl peroxide appears as odorless white powder or granules. moderately toxic. Sinks in water. (USCG, 1999)
반응 프로필
Benzoyl peroxide reacts exothermically withstrong acids, strong bases, amines, reducingagents, and sulfur compounds. Explosionshave been reported when it reacted withcarbon tetrachloride and ethylene (Bolt andJoyce 1947), lithium aluminum hydride(Sutton 1951), N,N-dimethyl aniline (Hornerand Betzel 1953), hot chloroform (NFPA1986), and methyl methacrylate (NFPA1986). Lappin (1948) reported an explosionwhen a bottle was opened. Organic matterentrapped in the threads of the bottleprobably reacted explosively with benzoylperoxide.
위험도
Highly toxic via inhalation. May explode spontaneously when dry (<1% of water). Never mix unless at least 33% water is present. Skin and upper respiratory tract irritant. Questionable carcinogen.
건강위험
The health hazard from benzoyl peroxideis low. It can cause irritation of the skin,mucous membranes, and eyes. An intraperitonealinjection of 250 mg/kg was lethal toadult mice. Systemic toxicity in humans isnot known. It may be mild to moderatelytoxic on an acute basis. The oral LD₅₀ valuein rats is 7710 mg/kg (NIOSH 1986). Itstoxicity from inhalation is low; an LC50 valueof 700 ppm in mice is suggested (ACGIH1986).
Benzoyl peroxide may cause gene damageand DNA inhibition. It has been foundto cause skin tumor. The evidence of its carcinogenicityin animals and humans is inadequate.
화재위험
Benzoyl peroxide can cause a major fire and explosion hazard. It is highly flammable and a strong oxidizer; autoignition temperature 80°C (176°F). It ignites instantly. The rate and violence of decomposition and the potential ease of such ignition or decomposition have been experimentally measured by Noller et al. (1964). Lead pipe deformation (LPD), pressure vessel test (PVT), and self-accelerating decomposition test (SADT) have been performed to measure these explosive characteristics. Heating 5 g of benzoyl peroxide in an aluminum tester containing an aperture vent and 6-atm rupture disk, caused the disk to blow up in 95 seconds when the aperture vent area was less than 174.7 mm². Redried material was more violent. The decomposition hazard was greatly reduced with wet and diluted benzoyl peroxide.
Noller et al. (1964) measured the SADT temperature at 82.2°C (180°F), above which the decomposition was self-accelerating, sudden, and produced smoke.
Benzoyl peroxide is a deflagrant, posing a severe explosion hazard. The compound is sensitive to heavy shock, such as impact or blows, as well as to friction and heat. Especially in the dry state, it is highly dangerous.
A water sprinkler should be used to extinguish fires. Water should be used to keep the containers cool.
색상 색인 번호
Benzoyl peroxide is an oxidizing agent widely employed in acne topical therapy. It is also used as a polymerization catalyst of dental or industrial plastics and as a decolorizing agent of flours, oils, fats, and waxes. Irritant or allergic dermatitis may affect workers in the electronics and plastics (epoxy resins and catalysts) industries, electricians, ceramic workers, dentists and dental technicians, laboratory technicians, bakers, and acne patients. As it was contained in candles, it also induced contact dermatitis in a sacristan. Patch tests may be irritant.
Safety Profile
Poison by intraperitoneal route.Can cause dermatitis, asthmatic effects, testicular atrophy,and vasodilation. An allergen and eye irritant. Humanmutation data reported. Questionable carcinogen withexperimental tumorigenic data. Moderate fire hazard by
잠재적 노출
Used as polymerization initiator, curing agent, and cross-linking agent.
Carcinogenicity
When repeatedly applied to the skin of mice, BPO was not carcinogenic . However, benzoyl peroxide is a tumor promoter in mice and hamsters, but has shown no complete carcinogenic or tumor-initiating activity . There has been one controversial Japanese report that was interpreted as BPO being a complete carcinogen. However, when the data were critically evaluated, it was found consistent with BPO acting as a skin tumor promoter and not as a carcinogen. The International Agency for Research on Cancer (IARC) has evaluated the carcinogenicity of benzoyl peroxide. They classified it as Group 3. This means there is limited or inadequate evidence of carcinogenicity for animals and inadequate or absent information for humans. In addition, there are other animals and in vitro studies that continue to support the lack of carcinogenic or mutagenic properties for BPO .
저장
Benzoyl peroxide should be stored in acool and well-ventilated area, isolated fromother chemicals and free of heating andelectrical installations. Dry compound maybe shipped in polyethylene-lined paper bagsor fiber containers packed in wooden boxeso.
운송 방법
UN3104 : Organic peroxide type C, solid, Hazard Class: 5.2; Labels: 5.2—Organic peroxide, Technical Name Required. UN3108 : Organic peroxide type E, solid, Hazard Class: 5.2; Labels: 5.2—Organic peroxide, Technical
Purification Methods
Dissolve benzoyl peroxide in CHCl3 at room temperature and precipitate it by adding an equal volume of MeOH or pet ether. Similarly it is precipitated from acetone by adding two volumes of distilled water. It has also been crystallised from 50% MeOH and from diethyl ether. Dry it under vacuum at room temperature for 24hours. Store it in a desiccator in the dark at 0o. When purifying in the absence of water it can be EXPLOSIVE, and operations should be done on a very small scale with adequate protection. Large amounts should be kept moist with water and stored in a refrigerator. [Kim et al. J Org Chem 52 3691 1987, Beilstein 9 IV 777.]
비 호환성
May explode when heated above melting point, 103 C. A strong oxidizer. Extremely explosionsensitive to heat, shock, friction, and concussion. May explode or cause fire on contact with reducing agents; combustible substances, organic substances, wood, paper, metal powders, lithium aluminum hydride. Violent reaction with alcohols, organic and inorganic acids, and amines.
폐기물 처리
Pretreatment involves decomposition with sodium hydroxide. The final solution of sodium benzoate, which is very biodegradable, may be flushed into the drain. Disposal of large quantities of solution may require pH adjustment before release into the sewer or controlled incineration after mixing with a noncombustible material.

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