카르베닉일린 디나트륨

한글명:카르베닉일린 디나트륨

카스 번호4800-94-6

상품명:Carbenicillin disodium

CBNumberCB7308325

분자식C17H19N2NaO6S

포뮬러 무게402.4

MOL 파일4800-94-6.mol

동의어(한글)

카르베닉일린디나트륨

카르베닉일린디나트륨(CARBENICILLINDISODIUM)

화학적 성질

녹는점	>190°C (dec.)
알파	+175～+190°(D/20℃)(c=4,H2O)(calculated on the dehydrous basis)
저장 조건	Inert atmosphere,2-8°C
용해도	H₂O: 50 mg/mL
물리적 상태	가루
색상	흰색에서 황백색까지
수소이온지수(pH)	5.5～7.5 (10g/l, 25℃)
수용성	물에 용해됩니다.
Merck	13,1801
BRN	5722128

위험 및 안전 성명

위험품 표기	Xn
위험 카페고리 넘버	42/43
안전지침서	22-36/37-36
유엔번호(UN No.)	UN 1170 3/PG 3
WGK 독일	2
RTECS 번호	ON9105000
F 고인화성물질	3-8-10
HS 번호	29411000
독성	LD50 i.p. in rats: >2000 mg/kg (Goldenthal)

그림문자(GHS)

카르베닉일린 디나트륨 MSDS

카르베닉일린 디나트륨 화학적 특성, 용도, 생산

개요
Carbenicillin is a broad-spectrum carboxypenicillin antibiotic. It is active against Gram-negative and certain Gram-positive bacteria, including S. pyogenes, S. epidermidis, P. mirabilis, P. vulgaris, E. coli, and P. aeruginosa (MICs = 0.19, 1.56, 1.56, 3.12, 3.12, and 50 μg/ml, respectively). It is also active against penicillinase-producing and non-producing strains of S. aureus (MICs = 1.56 and 12.5 μg/ml, respectively). Carbenicillin is protective against systemic S. pyogenes, P. vulgaris, E. coli, and S. aureus infection in a mouse model of systemic lethal infection with 50% protective dose (PD₅₀) values of 7.8, 224, 19.3, and 34 mg/kg, respectively. It also decreases viable colony counts in the kidney in a rat model of P. vulgaris or E. coli urinary tract infection when administered at a dose of 100 mg/kg. Formulations containing carbenicillin have previously been used in the treatment of upper and lower urinary tract infections and prostatitis.
화학적 성질
white Powder
용도
Carbenicillin disodium salt is a water-soluble antibiotic which is effective against gram-negative bacteria.Carbenicillin disodium salt is widely utilized as an antibiotic which is used to control bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. It has been involved in the study of the role of penicillin-sensitive transpeptidases in cell wall biosynthesis.
일반 설명
Carbenicillin was synthesized by Brain et al. of Beecham Research Laboratories in 1965. It was the first synthetic penicillin to show activity against Pseudomonas aeruginosa. Although its activity against the microorganism is not strong (MIC = 25 – 100 μg/mL), it is widely used against P. aeruginosa infections because of its low toxicity and the lack of other antibiotics suitable for use against this microorganism. Carbenicillin is mainly used clinically to treat urinary tract and respiratory tract infections and sepsis caused by Proteus, Escherichia coli, Klebsiella, and Pseudomonas aeruginosa.
Clinical Use
Carbenicillin disodium, disodium α-carboxybenzylpenicillin(Geopen, Pyopen), is a semisynthetic penicillin releasedin the United States in 1970, which was introduced inEngland and first reported by Ancred et al. in 1967.Examination of its structure shows that it differs from ampicillinin having an ionizable carboxyl group rather than anamino group substituted on the α-carbon atom of the benzylside chain. Carbenicillin has a broad range of antimicrobialactivity, broader than any other known penicillin, a propertyattributed to the unique carboxyl group. It has been proposedthat the carboxyl group improves penetration of themolecule through cell wall barriers of Gram-negativebacilli, compared with other penicillins.
Carbenicillin is not stable in acids and is inactivated bypenicillinase. It is a malonic acid derivative and, as such, decarboxylatesreadily to penicillin G, which is acid labile.Solutions of the disodium salt should be freshly prepared but,when refrigerated, may be kept for 2 weeks. It must be administeredby injection and is usually given intravenously.
Carbenicillin has been effective in the treatment of systemicand urinary tract infections caused by P. aeruginosa,indole-producing Proteus spp., and Providencia spp., all ofwhich are resistant to ampicillin. The low toxicity of carbenicillin,with the exception of allergic sensitivity, permits theuse of large dosages in serious infections. Most cliniciansprefer to use a combination of carbenicillin and gentamicinfor serious pseudomonal and mixed coliform infections. Thetwo antibiotics are chemically incompatible, however, andshould never be combined in an intravenous solution.

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