Cemandil sodium salt

한글명:Cemandil sodium salt

카스 번호42540-40-9

상품명:Cemandil sodium salt

CBNumberCB5430833

분자식C19H17N6NaO6S2

포뮬러 무게512.49

MOL 파일42540-40-9.mol

화학적 성질

녹는점	190-193°C
저장 조건	Inert atmosphere,Store in freezer, under -20°C
용해도	물에 잘 녹고, 메탄올에는 거의 녹지 않습니다.
물리적 상태	Solid
산도 계수 (pKa)	2.6-3.0(at 25℃)
색상	흰색에서 황백색까지
수용성	물에 자유롭게 용해됩니다. 메탄올에 난용성
CAS 데이터베이스	42540-40-9(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36/37/38-42/43

안전지침서

26-36

WGK 독일

RTECS 번호

XI0380000

HS 번호

2941906000

NFPA 704:

	0
2		0

그림문자(GHS)

Cemandil sodium salt 화학적 특성, 용도, 생산

화학적 성질
White Solid
용도
Cephalosporin antibacterial.
정의
ChEBI: A cephalosporin prodrug having (R)-O-formylmandelamido and N-methylthiotetrazole side-groups.
Mechanism of action
Cefamandole nafate has a formylated D-mandelic amide moiety at C-7. The formate ester is cleaved rapidly in the host to release the more active cefamandole. The esterification also apparently overcomes the instability of cefamandole when it is stored in dry form. This agent has increased activity against Haemophil us influenzae and some Gram-negative bacilli as compared with the first-generation cephalosporins. Loss of the 5-thio-l-methyl-l-H-tetrazole moiety (referred to sometimes by the acronym MT T) from C-3 is associated with prothrombin deficiency and bleeding problems as well as with an Antabuse-like acute alcohol intolerance. On the other hand, this grouping enhances potency and prevents metabolism by deacetylation. Like the other second-generation cephalosporins, cefamandole is more active against Gram-negative bacteria. The principle clinical use is for lower respiratory tract, skin and skin structures, and bone and joint infections as well as septicemia and urinary tract infections when the organisms are sensitive.
Clinical Use
The D-mandeloyl moiety of Cemandil sodium salt appears toconfer resistance to a few β-lactamases, since some β-lactamase–producing, Gram-negative bacteria (particularlyEnterobacteriaceae) that show resistance to cefazolin andother first-generation cephalosporins are sensitive tocefamandole. Additionally, it is active against some ampicillin-resistant strains of Neisseria and Haemophilus spp.Although resistance to β-lactamases may be a factor in determiningthe sensitivity of individual bacterial strains tocefamandole, an early study indicated that other factors,such as permeability and intrinsic activity, are frequentlymore important. The L-mandeloyl isomer is significantlyless active than the D-isomer.

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