크루크민

한글명:크루크민

카스 번호458-37-7

상품명:Curcumin

CBNumberCB4183426

분자식C21H20O6

포뮬러 무게368.38

MOL 파일458-37-7.mol

동의어(한글)

쿠르쿠민

커큐민

크루크민

화학적 성질

녹는점	183 °C
끓는 점	418.73°C (rough estimate)
밀도	0.93
증기 밀도	13 (vs air)
굴절률	1.4155-1.4175
인화점	208.9±23.6 °C
저장 조건	2-8°C
용해도	에탄올: 10mg/mL
물리적 상태	가루
산도 계수 (pKa)	8.09(at 25℃)
색상 색인 번호	75300
색상	오렌지 레드
색상	오렌지색
냄새	냄새 없는
pH 범위	Yellow (7.8) to red-brown (9.2)
수용성	약간 용해됨(뜨거움)
최대 파장(λmax)	430nm
Merck	14,2673
Solvent	Ethanol
Concentration	1 mCi/ml
Specific Activity	5-15 Ci/mmol
BRN	2306965
안정성	안정적이지만 빛에 민감할 수 있습니다. 강한 산화제와 호환되지 않습니다.
주요 응용	Cosmetics, drug-eluting stents, inhibition of formation of skin-wrinkles, treating alzheimer’s disease, skin diseases, coronary restenosis, diabetes, obesity, leukemia, neurofibromas, cancer, antimicrobial, antiviral, antiinflammatory, antiprostate cancer
InChIKey	VFLDPWHFBUODDF-FCXRPNKRSA-N
LogP	3.290 (est)
CAS 데이터베이스	458-37-7(CAS DataBase Reference)
EPA	Curcumin (458-37-7)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36/37/38

안전지침서

WGK 독일

RTECS 번호

MI5230000

위험 참고 사항

Irritant

TSCA

Yes

HS 번호

29145000

유해 물질 데이터

458-37-7(Hazardous Substances Data)

독성

LD50 Oral-Rat-12.200 mg/kg

NFPA 704:

	1
2		0

그림문자(GHS)

크루크민 MSDS

크루크민 화학적 특성, 용도, 생산

용도
산업 분야전문가 용.
순도시험

(1) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.
(2) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.
(3) 잔류용매 : 이 품목을 「파프리카추출색소」의 순도시험 (5)에 따라 시험할 때,
확인시험

이 품목을 에탄올에 용해(수용성제제일 때는 소량의 물로 용해시킨 후 에탄올로 채운다)하여 그 농도를 중크롬산칼륨용액(1→1,000)의 색조와 거의 같은 정도로 조정하여 시험용액으로 한다.
  (1) 시험용액은 황색을 나타내고 녹색의 형광을 나타낸다.
  (2) 시험용액 5mL에 황산 2mL를 가하여 교반하면 적색을 나타낸다.
  (3) 시험용액에 여지조각을 적시어 건조한 후 염산 수방울을 가한 다음 붕산용액(1→100)을 몇 방울 가하여 가열 건조하면 체리빛 적색을 나타내며, 이에 암모니아시액을 몇 방울을 가해주면 청색으로 변한다.
정의

이 품목은 심황(Curcuma longa Linné)의 건조근경을 에탄올, 유지 또는 유기용제(향신료올레오레진류의 추출용매)로 추출하여 얻어진 색소로서 쿠르쿠민(curcumin)을 주성분으로 하는 것이다. 다만, 색가조정, 품질보존 등을 위하여 희석제, 안정제 및 용제 등을 첨가할 수 있다.
개요
The main source of curcumin is the root of Zingiberaceae Curcuma aromatica, rhizome of Curcuma longa (Jiang Huang), Curcuma zedoaria, and Acorus calamus. Among them, Jiang Huang contains about 3–6% curcumin. The traditional Chinese medicine, Jiang Huang, is the root tuber of perennial herbaceous plant Curcuma longa L. of family Zingiberaceae. It was firstly recorded in the “Tang materia medica” (Xin Xiu Ben Cao). It is pungent, bitter, and warm and enters the liver and spleen meridians. It activates the blood, moves qi, dredges meridians, and alleviates pain. In India and other Asian countries, Jiang Huang has more than 6000?years of application history. In Japan, Jiang Huang has a long history of health care, and the people of Okinawa Island regarded Jiang Huang as a holy tribute to the emperor. Jiang Huang mainly comes from Taiwan, Fujian, Guangdong, Guangxi, Yunnan, and Tibet of China and other regions in East Asia and Southeast Asia. It grows in warm and humid climate and sunny environment with abundant rainfall and fears cold frost, drought, and flood. At present, Chinese Pharmacopoeia only included Jiang Huang and Yu Jin which contains curcumin, while curcumin is not included.
화학적 성질
orange crystalline powder
물리적 성질
Appearance: orange-brown crystalline powder and tastes a little bitter. It will turn into reddish brown in alkaline solution and yellow in neutral and acidic solution. It has strong stability against the reducing agent. It has excellent pigmentation which is not easy to fade. It is sensitive to light, heat, and iron ion. When PH is greater than 8, curcumin turns from yellow to red, which can be used as a pH indicator.
Solubility: insoluble in water or diethyl ether and soluble in ethanol, propylene glycol, acetic acid, and alkali solution.
Melting point: about 183 °C.
용도
Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). The curcuminoids are polyphenols and are responsible for the yellow color of turmeric. Curcumin can exist in at least two t
정의
ChEBI: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
일반 설명
Orange-yellow needles.
공기와 물의 반응
Slightly soluble in hot water .
반응 프로필
Curcumin is sensitive to light and changes in pH. Curcumin may react with oxidizing materials.
생물학적 활성
Antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNF α , IL-1, IL-6, PKC, EGFR, NF- κ B, I κ B kinase and more. Upregulates expression of PPAR γ , p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo .
Mechanism of action
Curcumin, the active component of turmeric (Curcuma longa), has been regarded as an anti-inflammatory and antioxidant agent . Particularly, it can scavenge reactive oxygen species, such as hydroxyl radicals, superoxide anion radicals, and nitrogen dioxide radicals. Additionally, it serves as an anti-inflammatory by down-regulating the production of pro-inflammatory cytokines (e.g., IL-1 and TNF-α) and inhibiting the activation of specific transcription factors (e.g., NF-κB and AP-1). Curcumin also demonstrates antiproliferative properties. Specifically, it inhibits UV radiation-induced skin cancer in SKH-1 hairless mice and reduces UVB-induced matrix metalloproteinase-1/3 expression in human dermal fibroblasts via MAPK-p38/JNK pathway suppression.
Clinical Use
1. Cholagogic effect could promote bile formation and secretion.
2. Hypolipidemic effect could reduce the level of cholesterol in the blood and prevent atherosclerosis.
3. Antibacterial and antiviral effect could inhibit Staphylococcus aureus and HIV.
4. Liver protection.
5. Anticancer and antitumor effect.
6. Help with the prevention of dementia.
7. Anti-inflammation and treatment of acne and dermatitis.
8. There are no reports of adverse effect of curcumin till now.
Purification Methods
Crystallise curcumin from EtOH or acetic acid. [Beilstein 8 IV 3697.]

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