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순도시험
(1) 융점 : 이 품목의 융점은 36.0～37.5℃이어야 한다.
(2) 용상 : 이 품목 1g을 70% 에탄올 4mL에 녹일 때, 그 액은 징명하여야 한다.
(3) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.
(4) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 10.0ppm 이하이어야 한다.
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확인시험
(1) 이 품목 0.1g을 황산 2mL에 녹인 다음 레소르신알콜용액(1→20) 2방울을 넣으면 암적색을 나타낸다.
(2) 이 품목 1g을 가온하여 녹인 다음 아황산수소나트륨시액 5mL를 넣고 흔들어 섞으면서 수욕중에서 가열하면 백색의 결정성덩어리가 생긴다.
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정량법
이 품목을 건조한 다음 약 1g을 정밀히 달아 향료시험법 중 알데히드류 및 케톤류함량측정법의 히드록실아민법 중 제2법에 따라 시험한다. 단, 방치시간은 15분간으로 한다.
0.5N 염산 1mL ＝ 75.07mg C8H6O3
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강열잔류물
이 품목의 강열잔류물은 0.05% 이하이어야 한다.
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화학적 성질
white crystalline solid
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출처
Reported found in the essential oils of Robinia pseudo-acacia and Eryngium poterium; in the oils of Spirea
ulmaria and of leaves of Doryphora sassafras; also reported found in Tahitian and Bourbon vanilla, camphor wood oil, violet flowers
concrete and absolute, burley tobacco, rabbiteye blueberry, melon, pepper, cooked chicken, sherry and dill.
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용도
Piperonal is an impurity of Tadalafil (T004500). Tadalafil impurity A.
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정의
ChEBI: An arenecarbaldehyde that is 1,3-benzodioxole substituted by a formyl substituent at position 5. It has been isolated from Piper nigrum.
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일반 설명
Colorless lustrous crystals.
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공기와 물의 반응
Slightly water soluble .
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반응 프로필
Piperonyl aldehyde is an aldehyde. Aldehydes are frequently involved in self-condensation or polymerization reactions. These reactions are exothermic; they are often catalyzed by acid. Aldehydes are readily oxidized to give carboxylic acids. Flammable and/or toxic gases are generated by the combination of aldehydes with azo, diazo compounds, dithiocarbamates, nitrides, and strong reducing agents. Aldehydes can react with air to give first peroxo acids, and ultimately carboxylic acids. These autoxidation reactions are activated by light, catalyzed by salts of transition metals, and are autocatalytic (catalyzed by the products of the reaction). The addition of stabilizers (antioxidants) to shipments of aldehydes retards autoxidation. Piperonyl aldehyde is sensitive to light. Piperonyl aldehyde may react with oxidizing materials.
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화재위험
Flash point data for Piperonyl aldehyde are not available. Piperonyl aldehyde is probably combustible.
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Safety Profile
Moderately toxic by
ingestion and intraperitoneal routes. Can
cause central nervous system depression. A
human skin irritant. Mutation data reported.
Combustible when exposed to heat or
flame; can react with oxidizing materials. See
also ALDEHYDES.
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신진 대사
In the animal body heliotropin undergoes the expected metabolic reaction involving oxidation to the corresponding acid (Williams, 1959).
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Purification Methods
Crystallise piperonal from aqueous 70% EtOH or EtOH/water. [Beilstein 19/4 V 225.]
