エトミドリン

エトミドリン 化学特性,用途語,生産方法

• 効能

  鎮痙薬, ムスカリン受容体拮抗薬

• Originator

  Smedolin,Yamanouchi,Japan,1976

• Manufacturing Process

  31.3 g of 1-oxo-3-(aminophenyl-p-ethoxypiperidino)-isoindoline (0.0892 mol) are dissolved in 500 ml of anhydrous N,N-dimethylformamide. To this solution 5.75 g of NaH (0.105 mol) and 7.24 ml of CH2CH2I (0.0945 mol) are added and the resulted mixture is heated at 70°C for 1 hour, and then poured into an excess of water. 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)- isoindoline (MP 106°C to 107°C) is obtained by crystallization with ligroin.
  1-oxo-2-ethyl-3-(iminophenyl-p-ethoxypiperidino)-isoindoline (MP 103°C to 104°C) is obtained as a byproduct with the above compound. This latter compound was reduced to produce 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-isoindoline.

• Therapeutic Function

  Muscle relaxant

エトミドリン 上流と下流の製品情報

エトミドリン 生産企業

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21590-92-1, エトミドリン キーワード