酢酸マフェニド

化学名:酢酸マフェニド

CAS番号.13009-99-9

英語名:Mafenide acetate

CBNumberCB7750274

MFC9H14N2O4S

MW246.28

MOL File13009-99-9.mol

别名

4-(アミノメチル)ベンゼンスルホンアミド·酢酸

酢酸マフェニド

4-(アミノメチル)ベンゼンスルホンアミド酢酸塩

酢酸マフェニド物理性質

融点	151-152°C
貯蔵温度	Inert atmosphere,2-8°C
溶解性	DMSO：可溶1mg/mL
外見	個体
色	白い
InChI	InChI=1S/C7H10N2O2S.C2H4O2/c8-5-6-1-3-7(4-2-6)12(9,10)11;1-2(3)4/h1-4H,5,8H2,(H2,9,10,11);1H3,(H,3,4)
InChIKey	UILOTUUZKGTYFQ-UHFFFAOYSA-N
SMILES	C1(=CC=C(CN)C=C1)S(=O)(=O)N.C(=O)(O)C
CAS データベース	13009-99-9(CAS DataBase Reference)

安全性情報

WGK Germany	3
国連危険物分類	IRRITANT
HSコード	2935904000
ストレージクラス	11 - Combustible Solids
毒性	LD50 in rats, mice (mg/kg): 2040, 1580 i.v. (Skulan, Hoppe)

危険有害性情報のコード(GHS)

酢酸マフェニド価格

製品番号	包装	価格	製品説明	購入
富士フイルム和光純薬株式会社(wako) W01TRCM110200	50mg	￥37500	酢酸マフェニド	購入
富士フイルム和光純薬株式会社(wako) W01COBQJ-2500	5g	￥10000	酢酸4-(アミノメチル)ベンゼンスルホンアミド	購入
富士フイルム和光純薬株式会社(wako) W01COBQJ-2500	1g	￥10000	酢酸4-(アミノメチル)ベンゼンスルホンアミド	購入
富士フイルム和光純薬株式会社(wako) W01COBQJ-2500	10g	￥27000		購入
Sigma-Aldrich Japan 1373008	200mg	￥57500	United States Pharmacopeia (USP) Reference Standard	購入

酢酸マフェニド化学特性,用途語,生産方法

効能
外用抗菌薬
説明
Mafenide Acetate, also known sulfamylon acetate, is a topical sulphonamide antimicrobial agent with activity against a wide range of microorganisms commonly associated with burn wound infections, including Pseudomonas aeruginosa and Staphylococcus aureus. It is primarily used for the prevention and treatment of burn wound infections. As a carbonic anhydrase inhibitor, sulfamylon acetate may cause metabolic acidosis and peripheral vasodilation. Therefore, its concomitant use with hyperbaric oxygen therapy should be carefully assessed. In burn patients requiring hyperbaric oxygen therapy, silver sulfadiazine may be considered as an alternative topical antimicrobial agent.
化学的特性
Mafenide acetate, USP is a white, crystalline powder which is freely soluble in water.
一般的な説明
4-(Aminomethyl)benzenesulfonamide acetate (Sulfamylon)is a homologue of the sulfanilamide molecule. It is not atrue sulfanilamide-type compound, as it is not inhibited byPABA. Its antibacterial action involves a mechanism thatdiffers from that of true sulfanilamide-type compounds.
This compound is particularly effective against Clostridiumwelchii in topical application and was used duringWorld War II by the German army for prophylaxis ofwounds. It is not effective orally. It is currently used aloneor with antibiotics in the treatment of slow-healing, infectedwounds.
Some patients treated for burns with large quantities ofthis drug have developed metabolic acidosis. To overcomethis adverse effect, a series of new organic salts was prepared. The acetate in an ointment base proved to be themost efficacious.

酢酸マフェニド上流と下流の製品情報

酢酸マフェニド生産企業

酢酸マフェニドスペクトルデータ(¹HNMR)

13009-99-9, 酢酸マフェニドキーワード

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酢酸マフェニド

危険有害性情報のコード(GHS)

酢酸マフェニド 価格

酢酸マフェニド 化学特性,用途語,生産方法

酢酸マフェニド 上流と下流の製品情報

酢酸マフェニド 生産企業

酢酸マフェニド スペクトルデータ(1HNMR)

13009-99-9, 酢酸マフェニド キーワード

酢酸マフェニド価格

酢酸マフェニド化学特性,用途語,生産方法

酢酸マフェニド上流と下流の製品情報

酢酸マフェニド生産企業

酢酸マフェニドスペクトルデータ(¹HNMR)

13009-99-9, 酢酸マフェニドキーワード