ゾルピデム

化学名:ゾルピデム

CAS番号.82626-48-0

英語名:Zolpidem

CBNumberCB6345253

MFC19H21N3O

MW307.39

MOL File82626-48-0.mol

别名

N,N,6-トリメチル-2-(4-メチルフェニル)イミダゾ[1,2-a]ピリジン-3-アセトアミド

ゾルピデム

N,N-ジメチル-2-[6-メチル-2-p-トリルイミダゾ[1,2-a]ピリジン-3-イル]アセトアミド

ゾルピデム物理性質

融点	189-191°C
比重(密度)	1.12±0.1 g/cm3(Predicted)
闪点	9℃
貯蔵温度	Store at RT
溶解性	45% (w/v) 2-ヒドロキシプロピル-β-シクロデキストリン水溶液: 0.3 mg/mL
酸解離定数(Pka)	6.2(at 25℃)
外見	個体
色	白い
水溶解度	<10mg/L(室温)
主な用途	臨床検査
InChI	1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
InChIKey	ZAFYATHCZYHLPB-UHFFFAOYSA-N
SMILES	[n]21c(nc(c2CC(=O)N(C)C)c3ccc(cc3)C)ccc(c1)C
CAS データベース	82626-48-0(CAS DataBase Reference)
NISTの化学物質情報	Zolpidem(82626-48-0)

安全性情報

主な危険性	Xi
Rフレーズ	36/37/38
Sフレーズ	26-36
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS 番号	NJ5109750
HSコード	2933996500
ストレージクラス	3 - Flammable liquids
Hazard Classifications	Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Flam. Liq. 2 STOT SE 1

危険有害性情報のコード(GHS)

ゾルピデム価格

製品番号	包装	価格	製品説明	購入
Sigma-Aldrich Japan Z103	5mg	￥48700	ゾルピデム ≥98% (HPLC), solid	購入
Sigma-Aldrich Japan Z103	25mg	￥158000	ゾルピデム ≥98% (HPLC), solid	購入
Sigma-Aldrich Japan Z-017	1mL	￥11200	ゾルピデム溶液 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?	購入
Sigma-Aldrich Japan Y0002139	Y0002139	￥19400	システム適合性用ゾルピデム CRS, European Pharmacopoeia (EP) Reference Standard	購入

ゾルピデム化学特性,用途語,生産方法

用途
睡眠導入薬
効能
催眠鎮静薬
説明
Zolpidem hemitamwe is a non-benzodiazepine hypnotic with specific agonist activity at type 1 benzodiazepine receptors, and is indicated for use in insomnia and other sleep disorders. Structurally zolpidem belongs to a chemically distinct class, thus lacking the side-effects and abuse potential of classical benzodiazepines. It is currently being studied as a pre-operative sedative.
化学的特性
Off-White Solid
使用
A selective benzodiazepine receptor agonist not related chemically to benzodiazepines
定義
ChEBI: An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.
一般的な説明
Zolpidem (Ambien, an imidazopyridine) andeszopiclone (Lunesta, a cyclopyrrolone) are nonbenzodiazepinesand have been introduced as short- and moderate-acting hypnotics, respectively. Zolpidem exhibits ahigh selectivity for the α1 subunit of benzodiazepinebindingsite on GABAA receptor complex, whereas eszopicloneis a “superagonist” at BzRs with the subunitcomposition α1β2γ2 and α1β2γ3. Zolpidem has a rapidonset of action of 1.6 hours and good bioavailability(72%), mainly because it is lipophilic and has no ionizablegroups at physiological pH. Food can prolong the time topeak concentration without affecting the half-life probablyfor the same reason. It has short elimination half-life, becauseits aryl methyl groups is extensively α-hydroxylatedto inactive metabolites by CYP3A4 followed by furtheroxidation by aldehyde dehydrogenase to the ionic carboxylicacid. The metabolites are inactive, short-lived, andeliminated in the urine. Its half-life in the elderly or the patientswith liver disease is increased. Therefore, dosingshould be modified in patients with hepatic insufficiencyand the elderly. Because it has longer elimination half-lifethan zaleplon, it may be preferred for sleep maintenance.It was the most commonly prescribed drug for insomniain 2001.

ゾルピデム上流と下流の製品情報

82626-48-0, ゾルピデムキーワード

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ゾルピデム

危険有害性情報のコード(GHS)

ゾルピデム 価格

ゾルピデム 化学特性,用途語,生産方法

ゾルピデム 上流と下流の製品情報

82626-48-0, ゾルピデム キーワード

ゾルピデム価格

ゾルピデム化学特性,用途語,生産方法

ゾルピデム上流と下流の製品情報

82626-48-0, ゾルピデムキーワード