イブチリド

イブチリド 化学特性,用途語,生産方法

• 効能

  抗不整脈薬, カリウムチャネル遮断薬

• 使用

  Cardiac depressant (anti-arrhythmic).

• 一般的な説明

  Ibutilide, N-{4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl}methanesulfonamide (Corvert), aclass III antiarrhythmic belonging to the methanesulfonanilideclass of agents, is indicated for rapid conversion ofatrial fibrillation or atrial flutter to normal sinus rhythm.Unlike dofetilide, it is not highly specific for the delayedrectifier potassium currents (Ikr) and does have some affinityfor sodium channels.

• 臨床応用

  Ibutilide (Corvert) is another methanesulfonanilide derivative , but unlike sotalol, it lacks any β-adrenergic blocking activity. Like sotalol, it exhibits electrophysiologic effects characteristic of Class III. Ibutilide is used only by intravenous infusion as its fumarate salt.

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122647-31-8, イブチリド キーワード