フマル酸

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H319：強い眼刺激

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P337+P313：眼の刺激が続く場合：医師の診断/手当てを受けること。

フマル酸 価格

フマル酸 化学特性,用途語,生産方法

• 外観

  白色の結晶又は結晶性の粉末

• 性質

  1. 名称
  和名：フマル酸
  英名：fumaric Acid
  IUPAC名：(2E)-but-2-enedioic acid

  2. 分子式
  C4H4O4

  3. 分子量
  116.07

  4. 融点
  300～302℃（封管中）

  5. 溶媒溶解性
  に可溶、水に難溶、に不溶。

• 定義

  本品は、次の化学式で表されるジカルボン酸である。

• 溶解性

  水に難溶。エタノールに可溶。アセトンに微溶。エタノールに溶けやすく、アセトンにやや溶けにくく、水に溶けにくい。

• 無機性値/有機性値

  302/80

• 解説

  フマル酸,不飽和の二塩基酸．いろいろな植物中に含まれる．生化学的には，トリカルボン酸サイクルの一員として，コハク酸の脱水素反応により生じる重要な代謝中間体．シス形のマレイン酸と幾何異性の関係にある．マレイン酸の異性化あるいはグリオキシル酸とマロン酸との縮合によって得られる．また工業的には，グルコースのフマル酸発酵によってつくられる．無色の針状結晶．融点287 ℃(封管中)．200 ℃ で昇華する．密度1.625 g cm－3．K1 9.3×10－4，K2  10－5(25 ℃)．水，エタノールに可溶，エーテル，アセトンに難溶，ベンゼンに不溶．230 ℃ で異性化脱水して無水マレイン酸になる．生体内では，水を付加したリンゴ酸やアンモニアを付加したアスパラギン酸の原料となっている．食品添加物，抗酸剤，合成樹脂や染料の原料に用いられる．

• 用途

  ポリマー類製造時のマレイン酸代替物、食品添加剤(ベーキングパウダー、清涼飲料水剤の酸味料)、抗酸化剤、ゴム、薬品、媒染剤の原料

• 用途

  有機合成原料、食品添加物(酸味剤)研究用。

• 化粧品の成分用途

  pH調整剤、香料

• 効能

  乾癬治療薬, 酸味料

• 説明

  Fumaric acid is an important kind of organic chemical raw materials as well as the intermediate of fine chemical products. Meanwhile, it is also an important kind of derivatives of maleic anhydride, being widely used in food, coatings, resins and plasticizers. In the food industry, fumaric acid, used as souring agent, can be applied to soft drinks, western-style wine, cold drinks, fruit juice concentrate, canned fruit, pickles and ice cream. As an acidic substance used as solid beverage gas production agent, it has excellent bubble durability with delicate product organization.
  Fumaric acid has been used as a food acidulant since 1946. As a food additive, it is used as an acidity regulator and can be denoted by the E number E297. Chemically it is an unsaturated dicarbonic acid and is part of the citric acid cycle.
  Fumaric acid is a common food additive included in many processed foods to keep them stable and to add tartness. The substance has a more sour flavor than citric acid, another common food additive. Fumaric acid occurs naturally in fumitory, bolete mushrooms, lichen and Iceland moss. As an additive, fumaric acid is produced synthetically, mainly from malic acid from apples. Fumaric acid as an additive is regulated under the Codex Alimentarius General Standard for Food Additives (GSFA), a collection of internationally recognized standards.The U.S. Food and Drug Administration considers it safe.

• 化学的特性

  Fumaric acid is naturally presented in Corydalis, mushrooms and fresh beef. Product precipitated from the water is monoclinic needle-like, prismatic or leaf-like white crystalline or crystalline powder. It is odorless with a special and strong sour, which is about 1.5 times that of the citric acid. It has a melting point 287 ° C, the boiling point of 290 ° C with subjecting to sublimation at temperature above 200 ° C. When being heated to 230 ° C, it will lose water and become maleic anhydride. Its co-boiling with water can produce DL-malic acid. It is soluble in ethanol, slightly soluble in water and ether, but insoluble in chloroform. The pH value of the 3% aqueous solution is 2.0 to 2.5 with a strong buffering performance, in order to maintain the pH of the aqueous solution at around 3.0. This product is non-toxic; rat-oral LD50: 8000mg/kg.

• 天然物の起源

  Reported found in several plants, Fumaria offcinalis L , Boletus scaber Boll and lean raw fsh

• 使用

  fumaric acid is used to add fragrance to products and to decrease product pH. It can also help keep the pH stable. It is generally used in cleansers. Fumaric acid is naturally occurring in plants, such as lichen and Iceland moss, and in animals. For example, the skin produces fumaric acid when exposed to light. It can also F be synthetically manufactured.

• 調製方法

  Commercially, fumaric acid may be prepared from glucose by the action of fungi such as Rhizopus nigricans, as a by-product in the manufacture of maleic and phthalic anhydrides, and by the isomerization of maleic acid using heat or a catalyst.
  On the laboratory scale, fumaric acid can be prepared by the oxidation of furfural with sodium chlorate in the presence of vanadium pentoxide.

• 製造方法

  By the action of certain fungi (Rhizopus nigricans) on glucose; by oxidation of furfural with sodium chlorate in the pres- ence of vanadium pentoxide.

• 定義

  Either of two isomers. Transbutenedioic acid (fumaric acid) is a crystalline compound found in certain plants. Cisbutenedioic acid (maleic acid) is used in the manufacture of synthetic resins. It can be converted into the trans isomer by heating at 120°C.

• 安全性

  フマル酸自体は比較的低い毒性を持つとされていますが大量生産と使用に伴う環境への影響は注意が必要です特に工業廃水として排出される際には生物への影響を最小限に抑えるための適切な処理が求められます

• 一般的な説明

  A colorless crystalline solid. The primary hazard is the threat to the environment. Immediate steps should be taken to limit spread to the environment. Combustible, though may be difficult to ignite. Used to make paints and plastics, in food processing and preservation, and for other uses.

• 空気と水の反応

  Slightly soluble in water.

• 健康ハザード

  Inhalation of dust may cause respiratory irritation. Compound is non-toxic when ingested. Prolonged contact with eyes or skin may cause irritation.

• 類似物

  フマル酸には幾何異性体が存在します。トランス体がフマル酸であり、シス体がマレイン酸です。

  

  図. フマル酸とマレイン酸の構造

  興味深い事に、これらの化合物は化学的性質が大きく異なります。具体的には、トランス体であるフマル酸は、マレイン酸に比べて分子内脱水縮合をしにくく、また、水への溶解度もマレイン酸と比べて非常に低いです。このような性質の違いは、これらの異性体における二つのカルボキシル基の立体的な位置関係で説明できます。その原理については以下の記事で詳しく説明しているので参考になさって下さい。
  ⇒

• 使用用途

  1. 殺菌剤としての利用

  本化合物は殺菌力を有しているため生鮮食品の殺菌剤として利用されています。 その作用機作は以下の通りです。

  ◇フマル酸の殺菌剤としての作用機作

  1. カルボキシル基が非解離の状態で菌体内に取り込まれる。
  2.  細胞質中でカルボキシル基が解離する事で、細胞質のpHが低下する。
  3. 上記②の結果、細胞質中の酵素活性が低下し、代謝異常などを誘発する事で菌が死滅する。

  2. 食品業界、畜産業界、医療分野での利用例

  フマル酸は食品添加物としての安全性が認められており、酸味剤、膨張剤、pH調整剤、調味料などに使用されています。畜産・農業の分野では飼料の添加物、植物の殺菌・殺藻剤として使用されています。また、工業の分野では合成樹脂や染料の原料として利用さています。医療の分野では、フマル酸から作られるフマル酸エステルが乾癬（かんせん）治療に効果があるとして研究が進められています。

  3. 生体内での役割

  

  図. クエン酸回路におけるリンゴ酸の反応

  フマル酸は酸素呼吸を行う生物のエネルギー生産過程で重要な役割を担っています。具体的には、クエン酸回路において、から生成され、へと変換される中間体として存在しています。

• 生産方法

  フマル酸は主に石油製品やバイオマスからの酸化によって製造されます特にマレイン酸からの異性化によってフマル酸が得られるのが一般的な方法ですこの化学反応は触媒の存在下で温度と圧力を調整して行われます

• 応用例（製薬）

  Fumaric acid is used primarily in liquid pharmaceutical preparations as an acidulant and flavoring agent. Fumaric acid may be included as the acid part of effervescent tablet formulations, although this use is limited as the compound has an extremely low solubility in water. It is also used as a chelating agent which exhibits synergism when used in combination with other true antioxidants.
  In the design of novel pelletized formulations manufactured by extrusion–spheronization, fumaric acid was used to aid spheronization, favoring the production of fine pellets. It has also been investigated as an alternative filler to lactose in pellets.
  Fumaric acid has been investigated as a lubricant for effervescent tablets, and copolymers of fumaric acid and sebacic acid have been investigated as bioadhesive microspheres.It has been used in film-coated pellet formulations as an acidifying agent and also to increase drug solubility.
  Fumaric acid is also used as a food additive at concentrations up to 3600 ppm, and as a therapeutic agent in the treatment of psoriasis and other skin disorders.

• 安全性プロファイル

  Poison by intraperitoneal route. Mildly toxic by ingestion and skin contact. A skin and eye irritant. Mutation data reported. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes.

• 安全性

  Fumaric acid is used in oral pharmaceutical formulations and food products, and is generally regarded as a relatively nontoxic and nonirritant material. However, acute renal failure and other adverse reactions have occurred following the topical and systemic therapeutic use of fumaric acid and fumaric acid derivatives in the treatment of psoriasis or other skin disorders. Other adverse effects of oral therapy have included disturbances of liver function, gastrointestinal effects, and flushing.
  The WHO has stated that the establishment of an estimated acceptable daily intake of fumaric acid or its salts was unnecessary since it is a normal constituent of body tissues.
  LD50 (mouse, IP): 0.1 g/kg
  LD50 (rat, oral): 9.3 g/kg

• 職業ばく露

  Fumaric acid is used in production of resins, polyesters, plasticizers, and alkyl surface coatings; as a food additive; as an antioxidant in resins; to make dyes.

• 概要

  フマル酸はその多機能性から多方面で利用される化合物です食品から医薬品工業製品の製造まで幅広く活用されておりこれからもその用途は拡大していくことが予想されます学ぶ価値のある興味深い物質の一つです

• 発がん性

  No evidence of carcinogenicity was found in several chronic studies with rats in which fumaric acid was added to the diet at concentrations up to 1.5%. As for dermal application, Swiss mice were treated topically twice weekly with a 1% solution in acetone (volume not specified). Moderate focal hyperplasia was found in the treated group, but no tumors developed.
  The inhibitory effect of fumaric acid on hepatocarcinogenesis was examined in male IBR mice fed 0.035% thioacetamide in the diet for 40 weeks and then fed a basal diet for 48 weeks. The inhibitory effect of 1% fumaric acid in the basal diet on thioacetamide carcinogenesis was so marked that no hepatic carcinomas were found in any of the 15 animals fed fumaric acid in combination with thioacetamide . Similar inhibitory effects of fumaric acid on forestomach and lung carcinogenesis in mice (that resulted from exposure to potassium naphthyridine-3-carboxylate) have been identified.

• 貯蔵

  Fumaric acid is stable although it is subject to degradation by both aerobic and anaerobic microorganisms. When heated in sealed vessels with water at 150–170°C it forms DL-malic acid.
  The bulk material should be stored in a well-closed container in a cool, dry place.

• 合成方法

  重縮合反応

• 純化方法

  Crystallise it from hot M HCl or water and dry it at 100o. [Beilstein 2 IV 2202.]

• 不和合性

  Fumaric acid undergoes reactions typical of an organic acid.

• 廃棄物の処理

  Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regula tions must be observed.

• 規制状況(Regulatory Status)

  GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules, suspensions, syrups, extended release and sustained action chewable tablets). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

フマル酸 上流と下流の製品情報

フマル酸 生産企業

Global(1341)Suppliers

フマル酸 スペクトルデータ(¹HNMR、IR1、IR2、MS、Raman)

110-17-8, フマル酸 キーワード