カルムスチン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H300：飲み込むと生命に危険

  H350：発がんのおそれ

  H360：生殖能または胎児への悪影響のおそれ

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

カルムスチン 価格

MSDS Information

• 1,3-Bis(2-chloroethyl)-1-nitrosourea

カルムスチン 化学特性,用途語,生産方法

• 外観

  白色～ほとんど白色粉末～結晶

• 用途

  抗悪性腫瘍薬。神経膠腫の治療

• 効能

  抗悪性腫瘍薬, アルキル化剤

• 商品名

  ギリアデル (エーザイ)

• 説明

  Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an alkylating agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis. Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase. Carmustine has been tested in clinical trials as a cytostatic agent for Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, malignant melanoma, glioblastoma, and other brain tumors.

• 化学的特性

  Carmustine is an orange-yellow crystalline solid or powder.

• 使用

  Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an alkylating agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis. Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase. Carmustine has been tested in clinical trials as a cytostatic agent for Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, malignant melanoma, glioblastoma, and other brain tumors.

• 定義

  ChEBI: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.

• 一般的な説明

  Orange-yellow solid.

• 空気と水の反応

  Insoluble in water.

• 反応プロフィール

  Carmustin decomposes rapidly in acid and in solutions above pH 7; most stable in petroleum ether or aqueous solution at pH 4.

• 危険性

  Extremely toxic, central nervous system depression, pulmonary fibrosis, renal and hepatic damage, cytotoxic, immunosuppressive, carcino- gen.

• 火災危険

  Flash point data for Carmustin are not available. Carmustin is probably combustible.

• 安全性プロファイル

  Confirmed carcinogen withexperimental carcinogenic and tumorigenic data. A humanpoison by parenteral route. An experimental poison byingestion, intravenous, intraperitoneal, parenteral, andsubcutaneous routes. Human systemic effects byparenteral, int

• 職業ばく露

  BCNU has been used since 1971 as an antineoplastic agent in the treatment of Hodgkin’slymphoma; multiple meyloma; and primary or metastatic brain tumors. It also has been reported to have antiviral, antibacterial, and antifungal activity, but no evidence was found that it is used in these ways. BCNU is not known to be naturally occurring. Health professionals who handle this drug (for example, pharmacists, nurses, and physicians) may possibly be exposed to BCNU during drug preparation, administration, or cleanup; however, the risks can be avoided through use of containment equipment and proper work practices

• 発がん性

  Bis(chloroethyl) nitrosourea (BCNU) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

• 環境運命予測

  It is generally assumed that BCNU exerts its cytotoxicity through the liberation of alkylating and carbamoylating moieties. An alkylating entity, particularly chloroethyl carbonium ion, is strongly electrophilic and can alkylate a variety of biomolecules, including the purine and pyrimidine bases of DNA. BCNU causes DNA interstrand cross-linking, which is associated with cytotoxicity. The carbamoylation of lysine residues of protein can inactivate certain enzymes, thus interfering with DNA and RNA synthesis and repair processes. The inhibition of glutathione reductase by this carbamoylation further contributes to cytotoxicity.

• 輸送方法

  UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required.

• 不和合性

  Acids and acid solutions above pH 7 cause rapid decomposition. Most stable at pH 4 in aqueous solution or petroleum ether.

• 廃棄物の処理

  It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

カルムスチン 上流と下流の製品情報

カルムスチン 生産企業

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カルムスチン スペクトルデータ(¹HNMR)

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