1,3,5-トリアザペンタン-2,5-ジオン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H228：可燃性固体

  H301：飲み込むと有毒

  H350：発がんのおそれ

  H360：生殖能または胎児への悪影響のおそれ

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

1,3,5-トリアザペンタン-2,5-ジオン 価格

MSDS Information

• 1-Methyl-1-nitrosourea

1,3,5-トリアザペンタン-2,5-ジオン 化学特性,用途語,生産方法

• 用途

  合成中間体、実験用発がん物質

• 説明

  Methylnitrosourea (MNU) is a methylated nitrosourea compound with alkylating,mutagenic, teratogenic, carcinogenic, and cytotoxic properties. The toxic effects of MNU are caused by the transfer of its methyl group to nucleobases in nucleic acids.

• 化学的特性

  Off-White to Pale Yellow Solid

• 使用

  Precursor of Diazomethane. It has a cytotoxicity effect. This product contains an undetermined amount of water

• 一般的な説明

  Pale yellow crystals or light yellow moist powder.

• 空気と水の反応

  Sensitive to humidity and light when pure. Insoluble in water. Slowly decomposes in water. Alkaline hydrolysis produces a highly toxic, irritating and explosive gas.

• 反応プロフィール

  1-Methyl-1-nitrosourea is incompatible with strong acids and bases. Also incompatible with water and nucleophilic reagents. Alkaline hydrolysis produces a highly toxic, irritating and explosive gas. Can detonate with (potassium hydroxide + methylene chloride) .

• 火災危険

  Flash point data for 1-Methyl-1-nitrosourea are not available; however, 1-Methyl-1-nitrosourea is probably combustible.

• 安全性プロファイル

  Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion and intravenous routes. Experimental reproductive effects. Human mutation data reported. Explodes at room temperature. Can detonate with (KOH + CHzCh). When heated to decomposition it emits toxic fumes of NOx.

• 発がん性

  N-Nitroso-N-methylurea is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

• 環境運命予測

  There is no evidence that MNU has ever been produced or used commercially; therefore, no data from human case reports or epidemiological studies are available. MNU is available in small quantities for research purposes and may be released into the environment with laboratory waste. In air, MNU is expected to exist solely as a vapor with an estimated vapor pressure of 2.9×10^-2 mmHg at 25℃. Vapor-phase MNU is expected to degrade in the atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of 10 days. MNU is expected to hydrolyze in moist soils; therefore, MNU adsorption and volatilization from soil are not expected to be prevalent. In water,MNUis expected to hydrolyze and has a halflife of 1.2 h at pH 7 and 20℃; therefore, volatilization, adsorption into suspended solids and sediments, biodegradation, and bioconcentration are not expected to be important processes in aquatic systems. Occupational exposure to MNU may occur through oral contact, inhalation, and/or dermal contact at workplaces where it is used as a research chemical. Potential exposure may occur during the preparation and administration ofMNUor during clean up. To avoid spills,MNU should be transported in securely sealed glass bottles or ampules, which should themselves be placed inside strong screw-cap or snap-top containers that will not open when dropped. Both bottle and the outside container should be appropriately labeled.

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