2-[3-(2-クロロエチル)-3-ニトロソウレイド]-2-デオキシ-D-グルコース

2-[3-(2-クロロエチル)-3-ニトロソウレイド]-2-デオキシ-D-グルコース 化学特性,用途語,生産方法

• 用途

  抗腫瘍薬

• 化学的特性

  Chlorozotocin is a nitrosourea compound that exists as ivory-coloredcrystals at room temperature. It is soluble in water and is stable in solution at room temperature for up to 3 hours and under refrigeration for 24 hours. The powder form of chlorozotocin is stable under refrigeration for two years. The spontaneous, nonenzymatic degradation of chlorozotocin results in formation of DNA-alkylating and protein-carbamoylating moieties (Chabner et al. 2001).

• 使用

  Chlorozotocin is a cytostatic agent that has been used to treat melanoma and multiple myeloma and cancer of the stomach, large intestine, pancreas, and lung (IARC 1990).

• 安全性プロファイル

  Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: anorexia, leukopenia, nausea or vomiting, thrombocytopenia. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. See also NITROSAMINES.

• 発がん性

  Chlorozotocin is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals and because it is a member of a well-defined, structurally related class of substances listed in the Report on Carcinogensas either known to be a human carcinogen or reasonably anticipated to be a human carcinogen.

2-[3-(2-クロロエチル)-3-ニトロソウレイド]-2-デオキシ-D-グルコース 生産企業

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