ドキセピン塩酸塩（異性体混合物）

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

ドキセピン塩酸塩（異性体混合物） 価格

ドキセピン塩酸塩（異性体混合物） 化学特性,用途語,生産方法

• 外観

  白色〜ほとんど白色, 結晶〜粉末

• 溶解性

  水に溶ける。

• 用途

  三環系抗うつ作用化合物です。 モノアミン神経伝達物質再取り込み阻害作用 を示します。

• 用途

  三環系抗うつ作用化合物です。 モノアミン神経伝達物質再取り込み阻害作用 を示します。

• 効能

  抗うつ薬, ヒスタミン受容体拮抗薬, セロトニン・ノルアドレナリン再取り込み阻害薬

• 説明

  Doxepin is a tricyclic antidepressant that binds to the serotonin (5-HT) transporter (SERT) and norepinephrine transporter (NET; K_ds = 68 and 29.5 nM, respectively). It is a histamine H₁ receptor antagonist (K_i = 1.23 nM). Doxepin selectively binds to SERT and NET over the dopamine transporter (DAT; K_d = 12,100 nM) and inhibits histamine H₁ over H₂, H₃, and H₄ receptors (K_is = 170, 39,810, and 15,135 nM, respectively). It also binds to the 5-HT₂ receptor, as well as to muscarinic acetylcholine and α₁-adrenergic receptors (α₁-ARs; K_ds = 27, 23, and 23.5 nM, respectively). Doxepin (10 mg/kg, i.p.) decreases allodynia and hyperalgesia in a mouse model of chronic constriction injury-induced neuropathic pain. It increases the distance traveled in the center of the open field test and reduces immobility time in the forced swim test in a mouse model of depression induced by chronic stress when administered orally at a dose of 15 mg/kg. Formulations containing doxepin have been used in the treatment of depression and insomnia.

• 化学的特性

  White Solid

• 使用

  Doxepin hydrochloride is a tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range.It is a antidepressant used clinically to treat anxiety and depression.

• 適応症

  Doxepin (Sinequan, Adapin) is a tricyclic antidepressant with potent H1 and H2 antagonistic effects. It also has antimuscarinic, antiserotonic, and anti-α-adrenergic activity. Use of 10 to 50 mg PO t.i.d. to q.i.d. has been shown to be effective in the treatment of primary acquired, chronic idiopathic urticaria, idiopathic cold urticaria, and for patients with anxiety or depression associated with their urticaria. Sedation and dry mouth are the most common side effects. Doxepin may interact with other drugs that are metabolized by the cytochrome P-450 system (ketoconazole, itraconazole, erythromycin, clarithromycin, etc.).

• 一般的な説明

  Doxepin, 3-dibenz[b,e]-oxepin-11(6H)ylidine-N,N-dimethyl-1-propanamine hydrochloride, N,N-dimethyl-3-(dibenz[b,e]oxepin-11(6H)-ylidene)propylamine (Sinequan, Adapin), isan oxa congener of amitriptyline, as can be seen from itsstructure.
  The oxygen is interestingly placed and should influenceoxidative metabolism as well as postsynaptic and presynapticbinding affinities. The (Z)-isomer is the more active, althoughthe drug is marketed as the mixture of isomers. Thedrug overall is a NE and 5-HT reuptake blocker with significantanticholinergic and sedative properties. It can be anticipatedthat the nor- or des- metabolite will contribute to theoverall activity pattern.

ドキセピン塩酸塩（異性体混合物） 上流と下流の製品情報

ドキセピン塩酸塩（異性体混合物） 生産企業

Global(385)Suppliers

ドキセピン塩酸塩（異性体混合物） スペクトルデータ(¹HNMR)

1229-29-4, ドキセピン塩酸塩（異性体混合物） キーワード