アンフェタミン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H225：引火性の高い液体および蒸気

  H370：臓器の障害

• 注意書き

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P260：粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

  P311：医師に連絡すること。

アンフェタミン 化学特性,用途語,生産方法

• 解説

  アンフェタミン．ベンゼドリン(benzedrine)ともいう．覚せい剤の一つ．ベンジルメチルケトンのオキシムを還元するか，またはホルムアミドと反応させてつくられる．アミン臭のある液体．沸点200～203 ℃．硫酸塩(融点320～322 ℃ 分解)は白色の結晶で，水に溶けやすく，中枢神経，交感神経の興奮作用をもつ．わが国では製造・使用が禁止されているが，外国ではやせ薬として使われる．

• 用途

  アンフェタミン（英語: amphetamine, alpha-methylphenethylamine）とは、間接型アドレナリン受容体刺激薬としてメタンフェタミンと同様の中枢興奮作用を持つ。アメリカでは商品名Adderallで販売され、適応は注意欠陥?多動性障害 (ADHD) のみである。強い中枢興奮作用と精神依存性、薬剤耐性がある。

• 効能

  中枢神経刺激薬

• 化学的特性

  Colorless, volatile liquid; characteristic strong odor; slight burning taste. Soluble in alcohol and ether; slightly soluble in water.

• 使用

  Stimulant (central).

• 世界保健機関（WHO）

  Amfetamine and its derivatives are potent central stimulants. Use of amfetamines has widely been discouraged due to abuse of their euphoric effect and their limited field of usefulness. Amfetamines have a place in the treatment of narcolepsy and in hyperkinetic syndrome in children. However, they are no longer recommended for use in obesity or depressive illness. Amfetamine is controlled under Schedule II of the 1971 Convention on Psychotropic Substances. (Reference: (UNCPS2) United Nations Convention on Psychotropic Substances (II), , , 1971)

• 一般的な説明

  Colored liquid with an amine odor. Used as a pharmaceutical, a central nervous system stimulant.

• 反応プロフィール

  Amines, such as D/L-AMPHETAMINE HYDROCHLORIDE, are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

• 危険性

  Flammable, moderate fire risk. Basis of a group of hallucinogenic (habit-forming) drugs that affect the central nervous system. Sale and use restricted to physicians. Production limited by law.

• 健康ハザード

  D/L-AMPHETAMINE HYDROCHLORIDE is classified as extremely hazardous. Probable lethal dose in humans is 5-50 mg/kg or 7 drops to 1 teaspoon for a 70 kg (150 lb.) person. Habit forming drug which affects the central nervous system. Excessive use may lead to tolerance and physical dependence. Death is possible.

• 火災危険

  Dangerous when exposed to heat or flames. Upon decomposition, nitrogen oxides are emitted. Can react with oxidizing materials.

• 安全性プロファイル

  A deadly human poison by an unspecified route. An experimental poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Experimental reproductive effects. Mutation data reported. A central nervous system stimulant. Overdoses cause hyperactivity, restlessness, insomnia, rapid pulse, rise in blood pressure, dilated pupils, dryness of the throat. Combustible when exposed to heat, flame, or oxidizers. When heated to decomposition it emits toxic fumes of NO,. To fight fire, use CO2, dry chemical, alcohol foam, water mist, fog. See other benzedrine entries.

• 職業ばく露

  Amphetamine is used as a pharmaceutical. It is a CNS stimulant.

• 環境運命予測

  Amphetamines are indirect acting sympathomimetics, producing their effects by inhibiting the transporters of dopamine, norepinephrine, and serotonin at the presynaptic nerve terminal. This increases the release of norepinephrine, dopamine, and serotonin and increased norepinephrine levels at central synapses, which further stimulates alpha and beta receptors. Some amphetamines also inhibit monoamine oxidase, preventing the breakdownof catecholamines. Thesemechanisms combine to produce the sympathomimetic and central nervous system (CNS) effects seen with amphetamine abuse.

• 輸送方法

  UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

• 不和合性

  Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

• 廃棄物の処理

  It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

アンフェタミン 上流と下流の製品情報

300-62-9, アンフェタミン キーワード