無水ブルシン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H300：飲み込むと生命に危険

  H330：吸入すると生命に危険

  H412：長期的影響により水生生物に有害

• 注意書き

  P304+P340：吸入した場合：空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。

  P320：特別な治療が緊急に必要である（このラベ ルの．．．を見よ）。

  P330：口をすすぐこと。

  P405：施錠して保管すること。

無水ブルシン 価格

無水ブルシン 化学特性,用途語,生産方法

• 外観

  白色の結晶性粉末

• 成分

  ブルシンは，フジウツギ科のマチン (馬銭)の種子からとれるアルカロイド。ストリキニンと同じ部分に含まれる。苦みがあり，ストリキニンと同じ神経毒だが，効力は 20分の1の弱さ。局所鎮痛剤に使用されたが，現在は使われない。

• 溶解性

  熱水に可溶。冷水, エタノールに難溶。酢酸エチル, グリセリンに可溶、ベンゼンに微溶。エタノールおよびクロロホルムにやや溶けやすく、水に溶けにくい。

• 解説

  2,3-dimethoxystrichnidin-10-one．C23H26N2O4(394.46)．ブルシンは，フジウツギ科マチンStrychnos nux-vomicaの成熟種子より得られる．ストリキノスアルカロイドの一つ．四水和物は融点105 ℃(無水物178 ℃)．[α]_D"－119～127°(クロロホルム)．pK1 6.04，pK2 11.7．λmax 263，301 nm(log ε 4.09，3.93)．ストリキニーネよりも水，有機溶媒に溶けやすい．同様に，猛烈なけいれん毒であり，微量を神経興奮薬として用いる．また，しばしば酸類のラセミ分割に用いられる．LD50 1 mg/kg(ラット，経口)．森北出版「化学辞典（第2版）

• 用途

  アミノ酸等の光学分割剤、TLCの分離能測定、硝酸塩の比色定量。

• 使用上の注意

  やや風解しやすい。

• 説明

  As a Chinese medicine, brucine was firstly recorded in Compendium of Materia Medica. The Chinese name for brucine is “Maqian” because it looks like ancient coins with horse icon, where “Ma” refers to “horse” and “qian” refers to “coins.” This traditional Chinese herb has cold, bitter, and toxic properties. It can be used to treat typhoid fever, throat pain, and lumps. Brucine is mainly extracted from the traditional Chinese medicine “Maqian.” In 1819, Pelletier and Caventou firstly isolated the alkaline brucine from the seeds and bark of Strychnos nux-vomica L.Brucine is the dry and mature seeds of Loganiaceae Evergreen tree plants including Strychnos nux-vomica L. and Strychnos pierriana A.W. Hill.

• 化学的特性

  White powder

• 物理的性質

  Appearance: white crystalline powder; tastes very bitter. Solubility: slightly soluble in water; soluble in ether, chloroform, ethanol, methanol, and other organic solvents . Melting point: 175–178°C. Specific optical rotation: 118°.

• 使用

  10,11-Dimethoxystrychnine can be used for antineoplastic, convulsant.

• 一般的な説明

  A white crystalline solid. Combustible but may require some effort to ignite. Toxic by inhalation (vapor, dust, etc.) and ingestion.

• 空気と水の反応

  Slightly soluble in water.

• 危険性

  Poison by ingestion and inhalation.

• 健康ハザード

  Chemical is toxic if inhaled, swallowed, or absorbed through skin. Inhalation produces intense bitter taste. Ingestion causes nausea, vomiting, restlessness, excitement, twitching, and (rarely) convulsions. Contact with dust irritates eyes.

• 火災危険

  Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fires.

• 农业用途

  Rodenticide: Used in the manufacture of other chemicals, in perfumes, as a medication for animals, and as a poison for rodents

• 製品名

  DOLCO MOUSE CEREAL®; PIED PIPER MOUSE SEED® (Brucine)

• 薬理学

  1. Analgesic effects: Brucine is reported to exert analgesic effects through both central and peripheral pathways. Possible mechanisms of the analgesic effects include blocking the voltage-gated sodium channel, inhibiting the synthesis of PGE2, acting on the adrenergic receptor and the L-arginine-NO pathway. Brucine (0.48mg/kg) can significantly elevate the pain threshold in mice.
  2. Anti-tumor effects: Studies have shown that brucine inhibits the cell proliferation in breast cancer, liver cancer, leukemia, and Ehrlich ascites tumors by inducing tumor cell apoptosis, inhibiting angiogenesis, reversing tumor multidrug resistance, and regulating the expression of various cytokines. In addition, at the dose of 320μg/ml, the invitro hepatocarcinoma cell growth inhibition rate of brucine is nearly 100%.
  3. Anti-pathogen effects: In vitro study shows that 0.1% brucine can completely inhibit the growth of Haemophilus influenzae, Streptococcus pneumoniae, and alpha Streptococcus and Mlicrococcus catarrhalis. At the dose of 500μg/ml, the inhibitory rate of brucine on human immunodeficiency virus reverse transcriptase is above 30%.
  4. Other pharmacological effects: Anti-inflammation, regulation of the immune system, regulation of the cardiovascular system, antitussive, expectorant, and antiasthenic and antibacterial effects.

• 臨床応用

  The applications of brucine include reducing swelling; resolving mass; activating meridians to stop pain; attenuating rheumatism, stubborn paralysis, and numbness paralysis; alleviating bruises; etc. It has been used for nearly a thousand years and achieved prominent clinical efficacy. In the clinical practice, brucine is used as a compatibility prescription or compound medicine in treating rheumatism, rheumatoid arthritis, stroke hemiplegia, dementia, retinopathy, and orthopedic and other surgical diseases.
  Brucine is the main active ingredient in Strychnos and plays an important role in treating diseases. However, brucine is also a toxic ingredient, which limits the scope of its clinical application. Further studies of its pharmacological effects and toxicity will improve its clinical application.

• 安全性プロファイル

  A poison by subcutaneous, intravenous, and intraperitoneal routes. An alkaloid-like strychnine, but one-sixth as toxic. When heated to decomposition it emits toxic fumes of Nx,. See also STRYCHNINE

• 純化方法

  Crystallise brucine once from water or aqueous Me2CO (as the tetrahydrate), then suspend it in CHCl3 and shake with anhydrous Na2SO4 (to dehydrate the brucine, which then dissolves). Precipitate it by pouring the solution into a large bulk of dry pet ether (b 40-60o), filter and heat to 120o in a high vacuum [Turner J Chem Soc 842 1951]. The tetrahydrate crystallises from a mixture of EtOH and H2O as colourless elongated needles [Eeles Acta Cryst 6 809 1953, Beilstein 27 III/IV 7875.] VERY POISONOUS

無水ブルシン 上流と下流の製品情報

無水ブルシン スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2)

357-57-3, 無水ブルシン キーワード