ChemicalBook > CAS DataBase List > 3-(4-METHYLBENZYLIDENE)CAMPHOR

3-(4-METHYLBENZYLIDENE)CAMPHOR

CAS No.36861-47-9
Chemical Name:3-(4-METHYLBENZYLIDENE)CAMPHOR
CBNumber:CB9366893
Molecular Formula:C18H22O
Formula Weight:254.37
MOL File:36861-47-9.mol

3-(4-METHYLBENZYLIDENE)CAMPHOR Property

Melting point 66-68°C
Boiling point 198-200 °C
Density 1.064±0.06 g/cm3(Predicted)
RTECS DT5099565
storage temp. Inert atmosphere,Room Temperature
solubility insoluble in H2O; ≥10 mg/mL in DMSO; ≥111.2 mg/mL in EtOH
form Solid
color White to off-white
BRN 9213949
LogP 3.385 (est)
CAS DataBase Reference 36861-47-9(CAS DataBase Reference)
EWG's Food Scores 4-7
FDA UNII 8I3XWY40L9
EPA Substance Registry System Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-3-[(4-methylphenyl)methylene]- (36861-47-9)
UNSPSC Code 41116107
NACRES NA.25

Safety

Hazard Codes :Xn
Risk Statements :63
Safety Statements :22-24/25-36/37
WGK Germany :2
TSCA :Yes
HS Code :2914399000

NFPA 704:

	1
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H410
Precautionary statements P273-P391-P501

3-(4-METHYLBENZYLIDENE)CAMPHOR Price More Price(3)

Brand: Sigma-Aldrich(India)
Product number: PHR2805
Product name : Methyl Benzylidene Camphor
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 400MG
Price: ₹16724.63
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 78551
Product name : 3-(4-Methylbenzylidene)camphor
Purity: ≥98.0% (GC)
Packaging: 250G
Price: ₹13358.05
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 61547
Product name : 3-(4-Methylbenzylidene)camphor
Purity: certified reference material, TraceCERT?
Packaging: 50MG
Price: ₹8627.53
Updated: 2022/06/14
Buy: Buy

3-(4-METHYLBENZYLIDENE)CAMPHOR Chemical Properties,Usage,Production

Chemical Properties White Solid
Uses 3-(4-Methylbenzyliden)camphor is an UV-B absorbing agent in sunscreen cosmetics of the type creams, lotions, lipsticks, sun oils, etc.
Uses 3-(4-Methylbenzylidene)camphor is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation. 4-Methylbenzylidene camphor(4-MBC) a UV-B ray filter, is an endocrine disruptors (ED).
Uses 4-(Methylbenzylidene)camphor (4-MBC), a UV-B ray filter, is an endocrine disruptors (ED).
Biological Activity 4-methylbenzylidene camphor (4-mbc) is an ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities.since the estrogen receptor (er) ligand type can influence transactivation, it is important to obtain information on molecular actions of nonclassical er agonists.
in vitro previous results of competitive binding assays using cytosolic protein preparations from xenopus hepatocytes demonstrated that 4-mbc could weakly bind to the er. in addition, 4-mbc at a 100 micromol/l was not able to replace estradiol from the receptor completely [1].
in vivo the estrogen target gene expression in uterus of long evans rats after exposure to 4-mbc was studied. results showed that 4-mbc could altere steady-state levels of mrnas encoding for er, progesterone receptor (pr), and androgen recepto in uterus of 12-wk-old offspring. to evaluate sensitivity to estradiol (e2), offspring were injected with e2, and killed 6 h later. acute up-regulation of pr and igf-i and down-regulation of er and androgen receptor by e2 were reduced in 4-mbc treated rats dose-dependently [2].
IC 50 PI3K; Akt; ERK1; ERK2
References [1] klann a, levy g, lutz i, müller c, kloas w, hildebrandt jp. estrogen-like effects of ultraviolet screen 3-(4-methylbenzylidene)-camphor (eusolex 6300) on cell proliferation and gene induction in mammalian and amphibian cells. environ res. 2005 mar;97(3):274-81.
[2] s. durrer, k. maerkel, m. schlumpf, et al. estrogen target gene regulation and coactivator expression in rat uterus after developmental exposure to the ultraviolet filter 4-methylbenzylidene camphor. endocrinology 146(5), 2130-2139 (2005).
[3] n. r. janjua, b. mogensen, a. m. andersson, et al. systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. journal of investigative dermatology 123, 57-61(2004).