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Heptane

CAS No.142-82-5
Chemical Name:Heptane
CBNumber:CB0426554
Molecular Formula:C7H16
Formula Weight:100.2
MOL File:142-82-5.mol

Heptane Property

Melting point −91 °C(lit.)
Boiling point 98 °C(lit.)
Density 0.684 g/mL at 20 °C
vapor density 3.5 (vs air)
vapor pressure 40 mm Hg ( 20 °C)
refractive index n20/D 1.397
Flash point 30 °F
storage temp. Store at +5°C to +30°C.
solubility acetone: miscible(lit.)
form Liquid
pka >14 (Schwarzenbach et al., 1993)
Specific Gravity 0.684 (20/4℃)
color ≤10(APHA)
Odor Gasoline.
Relative polarity 0.012
explosive limit 1-7%(V)
Odor Threshold 0.67ppm
Evaporation Rate 2.8
Water Solubility practically insoluble
λmax λ: 200 nm Amax: ≤1.0
λ: 225 nm Amax: ≤0.10
λ: 250 nm Amax: ≤0.01
λ: 300-400 nm Amax: ≤0.005
Merck 14,4659
BRN 1730763
Henry's Law Constant 0.901, 1.195, and 1.905(atm?m³/mol) at 26.0, 35.8, and 45.0 °C, respectively (dynamic headspace, Hansen et al., 1995)
Exposure limits NIOSH REL: TWA 85 ppm (350 mg/m³), 15-min ceiling 440 ppm (1,800 mg/m³), IDLH 750 ppm; OSHA PEL: TWA 500 ppm (2,000 mg/m³); ACGIH TLV: TWA 400 ppm, STEL 500 ppm (adopted).
Dielectric constant 1.9（20℃）
Stability Stable. Incompatible with oxidizing agents, chlorine, phosphorus. Highly flammable. Readily forms explosive mixtures with air.
InChIKey IMNFDUFMRHMDMM-UHFFFAOYSA-N
LogP 4.660
Surface tension 21.12mN/m at 293.15K
Indirect Additives used in Food Contact Substances HEPTANE
FDA 21 CFR 175.105; 175.300; 177.1580; 178.2650
CAS DataBase Reference 142-82-5(CAS DataBase Reference)
EWG's Food Scores 1-2
FDA UNII 456148SDMJ
NIST Chemistry Reference Heptane(142-82-5)
EPA Substance Registry System Heptane (142-82-5)
Absorption 0.10 at 225nm
0.40 at 210nm
1.0 at 197nm
UNSPSC Code 41116107
NACRES NB.21

Safety

Hazard Codes :F,Xn,N
Risk Statements :11-38-50/53-65-67
Safety Statements :9-16-29-33-60-61-62-23
RIDADR :UN 1206 3/PG 2
OEB :A
OEL :TWA: 85 ppm (350 mg/m3), Ceiling: 440 ppm (1800 mg/m3) [15-minute]
WGK Germany :3
RTECS :MI7700000
F :3-10
Autoignition Temperature :433 °F
TSCA :Yes
HazardClass :3
PackingGroup :II
HS Code :29011000
Hazardous Substances Data :142-82-5(Hazardous Substances Data)
Toxicity :LC (2 hr in air) in mice: 75 mg/l (Lazarew)
IDLA :750 ppm

NFPA 704:

	3
1

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H225-H304-H315-H336-H410
Precautionary statements P210-P233-P273-P301+P310-P303+P361+P353-P331

Heptane Price More Price(59)

Brand: Sigma-Aldrich(India)
Product number: H2198
Product name : Heptane
Purity: ReagentPlus?, 99%
Packaging: 1L
Price: ₹2753.7
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: H2198
Product name : Heptane
Purity: ReagentPlus?, 99%
Packaging: 2.5L
Price: ₹6144.45
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: RTC000091
Product name : Heptane
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 20ML
Price: ₹11723.78
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: H2198
Product name : Heptane
Purity: ReagentPlus?, 99%
Packaging: 20L
Price: ₹107486.78
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: H2198
Product name : Heptane
Purity: ReagentPlus?, 99%
Packaging: 200L
Price: ₹493200
Updated: 2022/06/14
Buy: Buy

Heptane Chemical Properties,Usage,Production

Description n-Heptane is a clear liquid which is highlyflammable and volatile with a mild, gasoline-like odor. Theodor threshold is 40- 547 ppm; also reported at 230 ppm.Molecular weight = 100.23; Specific gravity (H2O:l)= 0.68;Boiling point = 98.39C; FreezingMelting point= - 90.6℃;Vapor pressure = 40 mmHg at 25℃; Flash point= 一4℃;Autoignition temperature = 204℃.285℃. Explosivelimits:LEL= 1.1%; UEL= 6.7%.Hazard Identification(basedonNFPA-704 M Rating System): Health 1,Flammability 3, Reactivity 0. Practically insoluble in water;solubility = 0.0003%.
Chemical Properties n-Heptane is a clear liquid which is highly flammable and volatile with a mild, gasoline-like odor. The odor threshold is 40 547 ppm; also reported @ 230 ppm.
Chemical Properties n-Heptane is a flammable liquid, present in crude oil and widely used in the auto- mobile industry. For example, as a solvent, as a gasoline knock testing standard, as automotive starter fl uid, and paraffi nic naphtha. n-Heptane causes adverse health effects in occupational workers, such as CNS depression, skin irritation, and pain. Other compounds such as n-octane (CH 3 (CH 2 ) 6 CH 3 ), n-nonane (CH 3 (CH 2 ) 7 CH 3 ), and n-decane (CH 3 (CH 2 ) 8 CH 3 ) have different industrial applications. Occupational workers exposed to these compounds also show adverse health effects. In principle, manage- ment of these aliphatic compounds requires proper handling and disposal to avoid health problems and to maintain chemical safety standards for safety to workers and the living environment.
Physical properties Clear, colorless, very flammable liquid with a faint, pleasant odor resembling hexane or octane. Based on a triangle bag odor method, an odor threshold concentration of 670 ppb_v was reported by Nagata and Takeuchi (1990).
Uses Suitable for HPLC, spectrophotometry, environmental testing
Uses As standard in testing knock of gasoline engines.
Uses heptane is a solvent and viscosity-decreasing agent.
Production Methods Heptane is produced in refining processes. Highly purified heptane is produced by adsorption of commercial heptane on molecular sieves.
Definition A colorless liquid alkane obtained from petroleum refining. It is used as a solvent.
Definition heptane: A liquid straight-chainalkane obtained from petroleum,C₇H₁₆; r.d. 0.684; m.p. -90.6°C; b.p.98.4°C. In standardizing octanenumbers, heptane is given a valuezero.
Synthesis Reference(s) Tetrahedron Letters, 3, p. 43, 1962 DOI: 10.1007/BF01499754
General Description Clear colorless liquids with a petroleum-like odor. Flash point 25°F. Less dense than water and insoluble in water. Vapors heavier than air.
Air & Water Reactions Highly flammable. Insoluble in water.
Reactivity Profile HEPTANE is incompatible with the following: Strong oxidizers .
Hazard Toxic by inhalation. Flammable, dangerous fire risk.
Health Hazard VAPOR: Not irritating to eyes, nose or throat. If inhaled, will cause coughing or difficult breathing. LIQUID: Irritating to skin and eyes. If swallowed, will cause nausea or vomiting.
Fire Hazard FLAMMABLE. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area.
Chemical Reactivity Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Potential Exposure n-Heptane is used in graphics, textiles, adhesives, and coatings; as an industrial solvent and in the petroleum refining process; as a standard in testing knock of gasoline engines.
First aid If this chemical gets into the eyes,Iremove; anycontact lenses at once and irrigate immediately for at least 15 min, occasionally lifting upper and lower lids. Seek med-ical ;attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, includ-ing resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medi-cal attention. Give large quantities of water and induce :vomiting. Do not make an unconscious person vomit.
Source Schauer et al. (1999) reported heptane in a diesel-powered medium-duty truck exhaust at an emission rate of 470 g/km.
Identified as one of 140 volatile constituents in used soybean oils collected from a processing plant that fried various beef, chicken, and veal products (Takeoka et al., 1996).
Schauer et al. (2001) measured organic compound emission rates for volatile organic compounds, gas-phase semi-volatile organic compounds, and particle-phase organic compounds from the residential (fireplace) combustion of pine, oak, and eucalyptus. The gas-phase emission rate of heptane was 28.9 mg/kg of pine burned. Emission rates of heptane were not measured during the combustion of oak and eucalyptus.
California Phase II reformulated gasoline contained heptane at a concentration of 9,700 mg/kg.
Gas-phase tailpipe emission rates from gasoline-powered automobiles with and without catalytic converters were 1.82 and 268 mg/km, respectively (Schauer et al., 2002).
Environmental Fate Biological. Heptane may biodegrade in two ways. The first is the formation of heptyl hydroperoxide, which decomposes to 1-heptanol followed by oxidation to heptanoic acid. The other pathway involves dehydrogenation to 1-heptene, which may react with water forming 1- heptanol (Dugan, 1972). Microorganisms can oxidize alkanes under aerobic conditions (Singer and Finnerty, 1984). The most common degradative pathway involves the oxidation of the terminal methyl group forming the corresponding alcohol (1-heptanol). The alcohol may undergo a series of dehydrogenation steps forming heptanal followed by oxidation forming heptanoic acid. The acid may then be metabolized by β-oxidation to form the mineralization products, carbon dioxide and water (Singer and Finnerty, 1984). Hou (1982) reported hexanoic acid as a degradation product by the microorganism Pseudomonas aeruginosa.
Photolytic. The following rate constants were reported for the reaction of hexane and OH radicals in the atmosphere: 7.15 x 10^-12 cm³/molecule?sec (Atkinson, 1990). Photooxidation reaction rate constants of 7.19 x 10^-12 and 1.36 x 10^-16 cm³/molecule?sec were reported for the reaction of heptane with OH and NO3, respectively (Sablji? and Güsten, 1990). Based on a photooxidation rate constant 7.15 x 10^-12 cm³/molecule?sec for heptane and OH radicals, the estimated atmospheric lifetime is 19 h in summer sunlight (Altshuller, 1991).
Chemical/Physical. Complete combustion in air yields carbon dioxide and water vapor. Heptane will not hydrolyze because it has no hydrolyzable functional group.
storage Color Code- _Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with heptane you should be trained on itsproper handling and storage. Before entering confined spacewhere heptane may be present, check to make sure that anexplosive concentration does not exist. Store in tightlyclosed containers in a cool, well-ventilated area. Metalcontainers involving the transfer of this chemical should be grounded and bonded. Where possible, automatically pumpliquid from drums or other storage containers to processcontainers.Drums must be equipped with self-closingvalves, pressure vacuum bungs, and flame arresters. Useonly nonsparking tools and equipment, especially whenopening and closing containers of this chemical. Sources ofignition, such as smoking and open flames, are prohibitedwhere this chemical is used, handled, or stored in a mannerthat could create a potential fire or explosion hazard.Wherever this chemical is used, handled, manufactured, orstored, use explosion-proof electrical equipment and fittings.
Shipping UN1206 Heptanes, Hazard Class: 3; Labels: 3-Flammable liquid.
Toxicity evaluation The acute mechanism of toxicity is suspected be similar to other solvents that rapidly induce anesthesia-like effects, i.e., a ‘nonspecific narcosis’ because of disruption (solvation) of the integrity of the cellular membranes of the central nervous system (CNS). This disruptive narcosis may also contribute to the pathology seen with chronic toxicity, although the gamma diketone metabolite of n-heptane would be responsible for any delayed peripheral neurotoxicity seen in humans following chronic exposure, similar to the mechanism seen for hexane. Although the mechanism of toxicity of n-heptane, with respect to polyneuropathy, is believed to be similar to hexane, human exposures in the workplace are often a mixture of other solvents and the animal data are not compelling.
Heptane is generally considered to be less toxic than hexane but slightly more toxic than octane. This is probably because it is less volatile than the former but more volatile than the latter (consistent with the nonspecific narcotic mechanism of toxicity of volatile organic compounds). If it is aspirated into the lungs, however, n-heptane will cause adverse effects similar to those seen with petroleum distillates.
Incompatibilities May form explosive mixture with air. Strong oxidizers may cause fire and explosions. Attacks some plastics, rubber and coatings. May accumulate static electric charges that can ignite its vapors.
Toxics Screening Level The initial threshold screening level for heptane is 3500 μg/m3 based on an 8-hour averaging time.
Waste Disposal Dissolve or mix the material with a combustible solvent and burn in a chemical incinera tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.