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WY-14643

WY-14643 Structure
WY-14643
  • CAS No.50892-23-4
  • Chemical Name:WY-14643
  • CBNumber:CB9345027
  • Molecular Formula:C14H14ClN3O2S
  • Formula Weight:323.8
  • MOL File:50892-23-4.mol
WY-14643 Property
  • Melting point 155°C
  • Boiling point 514.4±50.0 °C(Predicted)
  • Density 1.2984 (rough estimate)
  • refractive index 1.5630 (estimate)
  • storage temp. Keep in dark place,Sealed in dry,Room Temperature
  • solubility Soluble in DMSO (up to 40 mg/ml).
  • form White crystalline solid
  • pka 2.99±0.10(Predicted)
  • color Off-white
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
  • FDA UNII 86C4MRT55A
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H302-H315-H319-H335-H350
  • Precautionary statements P201-P301+P312+P330-P302+P352-P305+P351+P338-P308+P313
WY-14643 Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: C7081
  • Product name : WY-14643
  • Purity: 
  • Packaging: 10MG
  • Price: ₹6137.78
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C7081
  • Product name : WY-14643
  • Purity: 
  • Packaging: 50MG
  • Price: ₹18640.65
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: C1323
  • Product name : [4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid
  • Purity: 
  • Packaging: 1G
  • Price: ₹7400
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: C1323
  • Product name : [4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid
  • Purity: 
  • Packaging: 5G
  • Price: ₹18200
  • Updated: 2022/05/26
  • Buy: Buy

WY-14643 Chemical Properties,Usage,Production

  • Description WY-14643 (50892-23-4) is a selective PPARα agonist (EC50=0.63, 32 and >100 μM for PPARα,γ and δ, respectively).1? Displays anti-inflammatory activity2 and reduces LPS-induced inflammation in alveolar epithelial cells3. Induces “browning” of white adipocytes in combined treatment with retinoic acid.4? Stimulates ADAM10-mediated proteolysis of? amyloid precursor protein in a mouse model.5 Down regulates NFkB transcriptional activity. Review.6
  • Uses A highly potent PPARα agonist
  • Uses WY-14643 has been used:
    • as a positive control for transfection and luciferase assay
    • to stimulate bone marrow–derived macrophages (BMDM) for autophagic flux analysis
    • to analyze the regulation of fatty acid metabolism-immune nexus (FAMIN) expression in cell culture

  • Definition ChEBI: Pirinixic acid is a member of pyrimidines, an organochlorine compound and an aryl sulfide. It is functionally related to an acetic acid.
  • General Description WY-14643 prevents lipopolysaccharide (LPS)-induced inflammation in synovial fibroblasts. It protects cortical neurons from pro-inflammatory mediator-induced cell injuries. WY-14643 has inhibitory effects on pro-inflammatory responses in microglia. It improves oxido-nitrosative stress in disease models and reduces the generation of reactive oxygen species (ROS), nitric oxide (NO) and lipid peroxidation end-products in the brain.
  • Biological Activity Selective PPAR α agonist (EC 50 values are 0.63, 32 and > 100 μ M at PPAR α , PPAR γ and PPAR δ respectively). Negatively inhibits NF- κ B transcriptional activity and decreases the inflammatory response in vitro and in vivo .
  • Biochem/physiol Actions Selective PPARα agonist.
  • Safety Profile Moderately toxic by ingestion. Suspected carcinogen with experimental carcinogenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, NOx and SOx
  • storage Store at RT
  • References 1) Forman et al. (1997), Hypolipidemic drugs, polyunsaturated fatty acids and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta; Proc. Natl. Acad. Sci. USA, 94 4312 2) Devchand et al. (1996), The PPARalpha-leukotriene B4 pathway to inflammation control; Nature, 384 39 3) Heckler et al. (2015), PPAR-a activation reduced LPS-induced inflammation in alveolar epithelial cells; Exp. Lung Res., 41 393 4) Wang et al. (2015), WY14643 combined with all-trans retinoic acid acts via p38 MAPK to induce “browning” of white adipocytes in mice; Genet. Mol. Res., 14 6978 5) Corbett et al. (2015), Activation of peroxisome proliferator-activated receptor alpha stimulates ADAM10-mediated proteolysis of APP; Proc. Natl. Acad. Sci. USA, 112 8445 6) Merk et al. (2015), Pirinixic acids: flexible fatty acid mimetics with various biological activities; Future Med. Chem., 7 1597
WY-14643 Preparation Products And Raw materials
Raw materials
Preparation Products
WY-14643 Suppliers
Global(191)Suppliers
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier：
    LEAPCHEM CO., LTD.
  • Tel：+86-852-30606658
  • Email：market18@leapchem.com
  • Country：China
  • ProdList：43340
  • Advantage：58
WY-14643 Spectrum
50892-23-4, WY-14643Related Search:
  • Inhibitor
  • Intracellular receptor
  • Inhibitors
  • 抑制剂
  • 高端化学
  • 其他生化试剂
  • 细胞生物学试剂
  • 代谢
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • PPAR and RXR Regulators
  • Gene Regulation and Expression
  • 匹立尼酸,10 MM DMSO 溶液
  • WY 14643,PPARALPHA激动剂
  • [4-氯-6-(2,3-茬胺基)-2-嘧啶硫代]乙酸*5
  • 2-((4-氯-6-(((2,3-二甲基苯基)氨基)嘧啶-2-基)硫基)乙酸
  • [4-CHLORO-6-(2,3-XYLIDINO)-2-PYRIMIDINYLTHIO]ACETIC ACID [4-氯-6-(2,3-茬胺基)-2-嘧啶硫代]乙酸
  • PPARΑ和PPARΓ激动剂(WY-14643)
  • [4-氯-6-(2,3-二甲代苯氨基)-2-嘧啶基]乙酸
  • [4-氯-6-(2,3-茬胺基)-2-嘧啶硫代]乙酸
  • 匹立尼酸
  • 皮利尼克酸
  • 50892-23-4
  • Pirinixic Acid, 10 mM in DMSO
  • WY 14643, PPARalpha agonist
  • 2-((4-Chloro-6-((2,3-dimethylphenyl)amino)pyrimidin-2-yl)thio)acetic acid
  • WY-14643 USP/EP/BP
  • 99.0%(LC&amp
  • Chloro Acid
  • [4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid &gt
  • CS-737
  • WY14643; PIRINIXIC ACID;WY 14643;WY-14643
  • WY-14643 - CAS 50892-23-4 - Calbiochem
  • WY-14643 (Pirinixic Acid)
  • pirinixic acid (WY 14643)
  • [[4-Chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl]thio]acetic acid
  • 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid, Pirinixic acid
  • 4-CHLORO-6-(2,3-XYLIDINO)-2- PYRIMIDINYLTHIOACETIC
  • (4-CHLORO-6-(2,3-XYLIDINO)-2-PYRIMIDYL-THIO)ACETICACID
  • Pirinixic
  • WY-14643
  • PIRINIXIC ACID
  • [4-CHLORO-6-(2,3-XYLIDINO)-2-PYRIMIDINYLTHIO]ACETIC ACID
  • (4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]-2-PYRIMIDINYL)THIOACETIC ACID
  • [4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]-2-PYRIMIDINYL]THIACETIC ACID
  • wyeth14,643
  • Acetic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-
  • NSC 310038
  • pirnixicacid
  • 4-chloro-6-(2,3-xylidino)-2-*pyrimidinylthioaceti
  • ((4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)-aceticaci
  • ((4-chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)-aceticaci
  • WY-14643/WY14643

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