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Infigratinib

Uses
Infigratinib Structure
Infigratinib
  • CAS No.872511-34-7
  • Chemical Name:Infigratinib
  • CBNumber:CB52589643
  • Molecular Formula:C26H31Cl2N7O3
  • Formula Weight:560.48
  • MOL File:872511-34-7.mol
Infigratinib Property
  • Melting point >211°C (dec.)
  • Boiling point 747.9±60.0 °C(Predicted)
  • Density 1.354
  • storage temp. -20°C
  • solubility Soluble in DMSO (up to 5 mg/ml)
  • form White solid.
  • pka 11.02±0.70(Predicted)
  • color White
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
  • FDA UNII A4055ME1VK
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Infigratinib Chemical Properties,Usage,Production

  • Uses BGJ 398 is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
  • Description NVP-BGJ398 (872511-34-7) is a potent and selective pan-FGFR inhibitor (IC50?= 0.9nM, 1.4 nM, 1.0 nM, and 60 nM for FGFR1,2,3,4 respectively).1? It has also been used in a mouse model of Achondroplasia (most common form of dwarfism) to correct pathological hallmarks of this condition.
  • Uses BGJ 398 is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
  • Definition ChEBI: BGJ-398 is a member of the class of phenylureas that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 2,6-dichloro-3,5-dimethoxyphenyl group, while the hydrogens attached to the other nitrogen are replaced by a methyl group and a 6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl group. It is a potent and selective fibroblast growth factor receptor inhibitor. It has a role as a fibroblast growth factor receptor antagonist and an antineoplastic agent. It is an aminopyrimidine, a N-arylpiperazine, a N-alkylpiperazine, a dichlorobenzene and a member of phenylureas.
  • brand name Truseltiq
  • General Description Class: receptor tyrosine kinase; Treatment: cholangiocarcinoma; Other name: NVP-BGJ398; Elimination half-life = 34 h; Protein binding = 96.8%
  • target FGFR1
  • IC 50 FGFR1~4 IC50 = 0.9, 1.4, 1.0, and 60 nM; VEGFR2 IC50 = 180 nM
  • References 1) Guagnano?et al.?(2011),?Discovery of 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)-1-methylurea (NVP-BGJ398),?a Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase?; J. Med. Chem.?54?7066 2) Komla-Ebri?et al.?(2016),?Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model; J. Clin. Invest.?126?1871
Infigratinib Preparation Products And Raw materials
Raw materials
Preparation Products
Infigratinib Suppliers
Global(210)Suppliers
  • Supplier：
    Biochempartner
  • Tel：0086-13720134139
  • Email：candy@biochempartner.com
  • Country：CHINA
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    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
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  • Supplier：
    Alchem Pharmtech,Inc.
  • Tel：8485655694
  • Email：sales@alchempharmtech.com
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    career henan chemical co
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  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
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Related articles

Infigratinib Spectrum
872511-34-7, InfigratinibRelated Search:
  • API
  • Inhibitor
  • Inhibitors
  • 信号转导通路激酶抑制剂
  • 抑制剂
  • FDA批准的配体
  • 药靶配体
  • 细胞生物学试剂
  • 血管生成
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • C26H31Cl2N7O3
  • 72511-34-7
  • BGJ398(NVP-BGJ398,INFIGRATINIB) |CAS 872511-34-7
  • 化合物INFIGRATINIB,10 MM DMSO 溶液
  • 3-(2,6-二氯-3,5-二甲氧基苯基)-1-[6-[[4-(4-乙基-1-哌嗪基)苯基]氨基]-4-嘧啶基]-1-甲基脲
  • 英菲格拉替尼
  • 磷酸非古替尼
  • BGJ398 (NVP-BGJ398),FGFR抑制剂
  • 英非替尼
  • 3-(2,6-DICHLORO-3,5-DIMETHOXYPHENYL)-1
  • BGJ398英非替尼INFIGRATINIB
  • NVP-BGJ398原料生产进口供应商
  • 化合物INFIGRATINIB
  • FGFR抑制剂(NVP-BGJ398)
  • 3-(2,6-二氯-3,5-二甲氧基苯基)-1-[6-[[4-(4-乙基哌嗪-1-基)苯基]氨基]嘧啶-4-基]-1-甲基脲
  • 872511-34-7
  • Infigratinib/BGJ398 (NVP-BGJ398)
  • Infigratinib, 10 mM in DMSO
  • 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-1-methylurea
  • Infigratinib
  • Apoptosis,Infigratinib,Fibroblast growth factor receptor,BGJ398,inhibit,Inhibitor,BGJ 398,FGFR
  • 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-[6-[4-(4-ethylpiperazin-1-yl)anilino]pyrimidin-4-yl]-1-methylurea
  • Infligratinib
  • BGJ-398
  • Infigratinib free base
  • Infigratinib (BGJ-398)
  • NVP-BGJ398(BGJ-398)
  • NVP-BGJ398(BGJ-398,Infigratinib)
  • BGJ
  • NVP-BGJ398; BGJ398; BGJ-398;INFIGRATINIB;BGJ 398
  • CS-218
  • 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-
  • BGJ398 (NVP-BGJ398);BGJ-398; BGJ 398; NVP BGJ398
  • Transcrocetinate
  • BGJ-398 phosphate,NVP-BGJ398 phosphate,Infigratinib phosphate
  • NVP-BGJ398 (Infigratinib)
  • NVP-BGJ398, >=98%
  • Urea, N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-
  • Urea, N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-, methanesulfonate
  • NVP-BGJ398 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea
  • 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea NVP-BGJ398
  • NVP-BGJ398
  • BGJ398 (NVP-BGJ398)
  • BGJ 398
  • 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea

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