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NVP-BSK805

NVP-BSK805 Structure
NVP-BSK805
  • CAS No.1092499-93-8
  • Chemical Name:NVP-BSK805
  • CBNumber:CB62561486
  • Molecular Formula:C27H28F2N6O
  • Formula Weight:490.55
  • MOL File:1092499-93-8.mol
NVP-BSK805 Property
  • Melting point 137℃
  • Boiling point 639.8±55.0 °C(Predicted)
  • Density 1.4
  • storage temp. Store at -20°C
  • solubility ≥20.95 mg/mL in DMSO; ≥3.45 mg/mL in H2O with gentle warming and ultrasonic; ≥4.75 mg/mL in EtOH with gentle warming and ultrasonic
  • form solid
  • pka 9.78±0.10(Predicted)
  • color Off-white to yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

NVP-BSK805 Chemical Properties,Usage,Production

  • Uses NVP-BSK805 is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively[1].
  • in vivo

    NVP-BSK805 (BSK 805; 150 mg/kg, p.o.) blocks STAT5 phosphorylation, splenomegaly, and leukemic cell spreading in a Ba/F3 JAK2V617F cell-driven mouse model[1].
    NVP-BSK805 (50, 75, and 100 mg/kg, p.o.) also suppresses rhEpo-mediated polycythemia and splenomegaly in BALB/c mice[1].

  • target JAK2
  • IC 50 JAK2 JH1: 0.48 nM (IC50); FL JAK2 V617F: 0.56 nM (IC50); FL JAK2 wt: 0.58 nM (IC50); TYK2 JH1: 10.76 nM (IC50); JAK3 JH1: 18.68 nM (IC50); JAK1 JH1: 31.63 nM (IC50)
  • References [1] Baffert F, et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9(7):1945-55. DOI:10.1158/1535-7163.MCT-10-0053
    [2] Cheon JH, et al. The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1176-1182. DOI:10.1016/j.bbrc.2017.06.178
NVP-BSK805 Preparation Products And Raw materials
Raw materials
Preparation Products
NVP-BSK805 Suppliers
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NVP-BSK805 Spectrum
1092499-93-8, NVP-BSK805Related Search:
  • Inhibitor
  • STAT
  • JAK
  • Inhibitors
  • 抑制剂
  • 药靶配体
  • 标准品
  • 细胞生物学试剂
  • 蛋白酪氨酸激酶
  • 小分子抑制剂，天然产物
  • C27H28F2N6O2HCl
  • C27H28F2N6O
  • 化合物 NVP-BSK805
  • 4-(2,6-二氟-4-(3-(1-(哌啶-4-基)-1H-吡唑-4-基)喹喔啉-5-基)苄基)吗啉
  • NVP-BSK805游离态
  • JAK2抑制剂(NVP-BSK805 DIHYDROCHLORIDE)
  • 8-[3,5-二氟-4-(4-吗啉基甲基)苯基]-2-[1-(4-哌啶基)-1H-吡唑-4-基]喹喔啉
  • 1092499-93-8
  • 8-{3,5-difluoro-4-[(morpholin-4-yl)methyl]phenyl}-2-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]quinoxaline
  • NVP-BSK805(freebase)
  • NVP-BSK805 USP/EP/BP
  • Quinoxaline, 8-[3,5-difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
  • NVP-GSK 805
  • CS-550
  • BSK 805; BSK-805; BSK805; NVP-BSK 805
  • CS-1571
  • NVP-BSK805 - BSK 805
  • 4-(2,6-Difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine
  • BSK-805
  • BSK805
  • BSK 805
  • 8-(3,5-difluoro-4-(morpholinomethyl)phenyl)-2-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxaline
  • 8-[3,5-Difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]quinoxaline
  • NVP-BSK805 dihydrochloride
  • NVP-BSK805
  • NVP-BSK805 2HCl

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