ChemicalBook > CAS DataBase List > 3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide

3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide

3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide Structure
3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide
  • CAS No.1874276-76-2
  • Chemical Name:3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide
  • CBNumber:CB33142692
  • Molecular Formula:C22H23F3N8O
  • Formula Weight:472.47
  • MOL File:1874276-76-2.mol
3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide Property
  • Boiling point 592.7±50.0 °C(Predicted)
  • Density 1.387±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
  • form A crystalline solid
  • pka 7.65±0.70(Predicted)
  • color Light yellow to yellow
  • FDA UNII E0YF0M8O09
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide Chemical Properties,Usage,Production

  • Uses Darovasertib (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. Darovasertib has the potential for uveal melanoma research[1][2].
  • in vivo

    Darovasertib (LXS196; compound 9) (15, 30, 75, 150 mg/kg, P.O., mice) shows improved efficacy (regression) in a 92.1 GNAQ uveal melanoma xenograft model in a dose-dependently manner[2].

    Animal Model:Mice implanted with 92.1 GNAQ mutant uveal melanoma cells[2].
    Dosage:15, 30, 75, 150 mg/kg
    Administration:P.O. (bid) for 35 days
    Result:Dose-dependently suppressed the tumor growth.
  • IC 50 PKCα: 1.9 nM (IC50); PKCθ: 0.4 nM (IC50); GSK3β: 3.1 μM (IC50)
  • References [1] Protein Kinase C Inhibitor LXS196
    [2] US20180179181.
3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide Preparation Products And Raw materials
Raw materials
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3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide Spectrum
1874276-76-2, 3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamideRelated Search:
  • 抑制剂
  • 药靶配体
  • 贝尔卡主打
  • 细胞生物学试剂
  • C22H23F3N8O
  • IDE-196;LXS-196;NVP-LXS-196
  • 化合物LXS196,10 MM DMSO 溶液
  • 3-氨基-N-(3-(4-氨基-4-甲基哌啶-1-基)吡啶-2-基)-6-(3-(三氟甲基)吡啶-2-基)吡嗪-2-甲酰胺
  • 化合物LXS196
  • 3-氨基-N-[3-(4-氨基-4-甲基-1-哌啶基)-2-吡啶基]-6-[3-(三氟甲基)-2-吡啶基]-2-吡嗪甲酰胺
  • 蛋白激酶C(PKC)抑制剂(LXS196)
  • 1874276-76-2
  • Darovasertib, 10 mM in DMSO
  • Darovasertib (LXS-196)
  • LXS-196 (NVP-LXS196)
  • Protein kinase C,Darovasertib,IDE196,LXS-196,Inhibitor,PKC,LXS 196,IDE-196,IDE 196,inhibit
  • Darovasertib
  • 2-Pyrazinecarboxamide, 3-amino-N-[3-(4-amino-4-methyl-1-piperidinyl)-2-pyridinyl]-6-[3-(trifluoromethyl)-2-pyridinyl]-
  • LXS196,IDE196
  • IDE-196
  • NVP-LXS196; NVPLXS196; NVP LXS196; LXS-196; LXS 196; LXS196; LXS-196
  • EOS-61826
  • NVP-LXS196
  • LXS-196
  • 3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide

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