ChemicalBook > CAS DataBase List > N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine

N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine

N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Structure
N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
  • CAS No.300842-64-2
  • Chemical Name:N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
  • CBNumber:CB72516201
  • Molecular Formula:C21H17BrN4
  • Formula Weight:405.29
  • MOL File:300842-64-2.mol
N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Property
  • Boiling point 607.7±55.0 °C(Predicted)
  • Density 1.441
  • storage temp. Store at -20°C
  • solubility DMSO:13.0(Max Conc. mg/mL);32.08(Max Conc. mM)
    DMF:0.5(Max Conc. mg/mL);1.23(Max Conc. mM)
    DMF:PBS (pH 7) (1:10):0.09(Max Conc. mg/mL);0.22(Max Conc. mM)
    Ethanol:0.2(Max Conc. mg/mL);0.49(Max Conc. mM)
  • form A crystalline solid
  • pka 5.46±0.10(Predicted)
  • color Light yellow to yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Chemical Properties,Usage,Production

  • Uses NVP-ACC789, is an inhibitor of human VEGFR-1, VEGFR-2 (mouse VEGFR-2), VEGFR-3 and PDGFR-β with IC50s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively.
  • in vivo

    NVP-ACC789 which is given in daily oral doses for 6 days blocks VEGF-induced angiogenesis in a dose-dependent manner. NVP-ACC789 also inhibits the response to bFGF to some extent, but the dose-response curve is not linear for NVP-ACC789[1].

  • IC 50 VEGFR-2: 0.02 μM (IC50); VEGFR-1: 0.38 μM (IC50); mVEGFR-2: 0.23 μM (IC50); VEGFR-3: 0.18 μM (IC50); PDGFR-β: 1.4 μM (IC50)
N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Preparation Products And Raw materials
Raw materials
Preparation Products
N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Suppliers
Global(55)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Career Henan Chemica Co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：laboratory@coreychem.com
  • Country：China
  • ProdList：30231
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
  • Supplier：
    Henan Fengda Chemical Co., Ltd
  • Tel：+86-371-86557731<br/>+86-13613820652
  • Email：info@fdachem.com
  • Country：China
  • ProdList：20235
  • Advantage：58
  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
  • ProdList：52924
  • Advantage：58
N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Spectrum
300842-64-2, N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamineRelated Search:
  • 抑制剂
  • 化合物NVP-ACC789,10 MM DMSO 溶液
  • N-(3-溴-4-甲基苯基)-4-(吡啶-4-基甲基)酞嗪-1-胺
  • 化合物NVP-ACC789
  • N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺
  • 300842-64-2
  • NVP-ACC789, 10 mM in DMSO
  • 1-Phthalazinamine, N-(3-bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-
  • NVP ACC789,Platelet-derived growth factor receptor,inhibit,ZK 202650,PDGFR,NVPACC789,Inhibitor,ZK-202650,ACC789,NVP-ACC789,VEGFR,ACC 789,NVP-ACC-789,Vascular endothelial growth factor receptor
  • N-(3-Bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
  • ACC-789; ZK-202650; NVP-ACC-789;ACC789;ACC 789
  • ACC-789 (NVP-ACC789)
  • NVP-ACC-789
  • ZK 202650
  • Acc-789
  • N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine

Home

My