ChemicalBook > CAS DataBase List > GNE-490

GNE-490

GNE-490 Structure
GNE-490
  • CAS No.1033739-92-2
  • Chemical Name:GNE-490
  • CBNumber:CB92621136
  • Molecular Formula:C18H22N6O2S
  • Formula Weight:386.47
  • MOL File:1033739-92-2.mol
GNE-490 Property
  • storage temp. 4°C, protect from light
  • solubility DMSO : ≥ 100 mg/mL (258.75 mM)
  • form Solid
  • color White to off-white
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

GNE-490 Chemical Properties,Usage,Production

  • Description GNE-490 is a highly selective pan-PI3K inhibitor, demonstrating selectivity over mTOR.
  • Uses GNE-490, a (thienopyrimidin-2-yl)aminopyrimidine, is a potent pan-PI3K inhibitor with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for ?PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50=750 nM). GNE-490 shows potent suppression efficacy profile against MCF7.1 breast cancer xenograft model[1].
  • IC 50 PI3Kα: 3.5 nM (IC50); PI3Kβ: 25 nM (IC50); PI3Kδ: 5.2 nM (IC50); PI3Kγ: 15 nM (IC50); mTOR: 750 nM (IC50)
  • References [1] Daniel P Sutherlin, et al. Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer. J Med Chem. 2010 Feb 11;53(3):1086-97. DOI:10.1021/jm901284w
GNE-490 Preparation Products And Raw materials
Raw materials
Preparation Products
GNE-490 Suppliers
Global(34)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Career Henan Chemica Co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：laboratory@coreychem.com
  • Country：China
  • ProdList：30231
  • Advantage：58
  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
  • ProdList：52924
  • Advantage：58
  • Supplier： SYN|thesis med chem P/L
  • Tel：+86-021-50720296
  • Email：service@synkinase.com
  • Country：China
  • ProdList：266
  • Advantage：58
GNE-490 Spectrum
1033739-92-2, GNE-490Related Search:
  • 抑制剂
  • 化合物GNE-490,10 MM DMSO 溶液
  • 化合物GNE-490
  • 2-(2-氨基-4-甲基-5-嘧啶基)-ALPHA,ALPHA-二甲基-4-(4-吗啉基)噻吩并[3,2-D]嘧啶-6-甲醇
  • 1033739-92-2
  • GNE-490, 10 mM in DMSO
  • 2-[2-(2-amino-4-methylpyrimidin-5-yl)-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]propan-2-ol
  • PI3Kβ,GNE 490,PI3Kδ,Mammalian target of Rapamycin,mTOR,GNE-490,MCF7.1,PI3K,PI3Kα,Phosphoinositide 3-kinase,PI3Kγ,breast cancer,Inhibitor,GNE490,inhibit
  • 2-(2-(2-amino-4-methylpyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol
  • Thieno[3,2-d]pyrimidine-6-methanol, 2-(2-amino-4-methyl-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)-
  • CS-2657
  • GNE490;GNE 490
  • 2-(2-Amino-4-methyl-5-pyrimidinyl)-alpha,alpha-dimethyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidine-6-methanol
  • GNE-490

Home

My