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GNE 7915

GNE 7915 Structure
GNE 7915
  • CAS No.1351761-44-8
  • Chemical Name:GNE 7915
  • CBNumber:CB02667096
  • Molecular Formula:C19H21F4N5O3
  • Formula Weight:443.4
  • MOL File:1351761-44-8.mol
GNE 7915 Property
  • Melting point 143 - 144°C
  • Boiling point 629.9±65.0 °C(Predicted)
  • Density 1.404±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility Chloroform (Slightly), DMSO (Slightly)
  • form solid
  • pka 2.80±0.10(Predicted)
  • color Off-white to light yellow
  • CAS DataBase Reference 1351761-44-8
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

GNE 7915 Chemical Properties,Usage,Production

  • Uses GNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2).
  • Uses Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical]
GNE 7915 Preparation Products And Raw materials
Raw materials
Preparation Products
GNE 7915 Suppliers
Global(108)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
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    career henan chemical co
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  • Supplier：
    TargetMol Chemicals Inc.
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    InvivoChem
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  • Email：sales@invivochem.cn
  • Country：United States
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GNE 7915 Spectrum
1351761-44-8, GNE 7915Related Search:
  • api
  • Inhibitors
  • 抑制剂
  • 合成有机化合物配体
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • C19H21F4N5O3
  • C26H29F4N5O6S
  • 化合物GNE7915,10 MM DMSO 溶液
  • GNE7915,LRRK2抑制剂
  • 化合物GNE7915
  • 4-[[4-(乙基氨基)-5-(三氟甲基)嘧啶-2-基]氨基]-2-氟-5-甲氧基苯基](4-吗啉基)甲酮
  • (4-((4-(乙基氨基)-5-(三氟甲基)嘧啶-2-基)氨基)-2-氟-5-甲氧基苯基)(吗啉代)甲酮
  • 1351761-44-8
  • GNE-7915, 10 mM in DMSO
  • GNE7915, LRRK2 inhibitor
  • LRRK2,inhibit,GNE-7915,Inhibitor,Leucine-rich repeat kinase 2,GNE 7915
  • GNE 7915 USP/EP/BP
  • Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-
  • GNE7915; GNE 7915
  • CS-1279
  • (4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone
  • (4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol
  • GNE-7915, >=98%
  • [4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone
  • GNE 7915

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