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GNE-6640

GNE-6640 Structure
GNE-6640
  • CAS No.2009273-67-8
  • Chemical Name:GNE-6640
  • CBNumber:CB64693453
  • Molecular Formula:C20H18N4O
  • Formula Weight:330.38
  • MOL File:2009273-67-8.mol
GNE-6640 Property
  • Boiling point 595.5±50.0 °C(Predicted)
  • Density 1.308±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMF:1.0(Max Conc. mg/mL);3.03(Max Conc. mM)
    DMSO:3.0(Max Conc. mg/mL);9.08(Max Conc. mM)
    DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.91(Max Conc. mM)
  • form A solid
  • pka 8.23±0.15(Predicted)
  • color White to off-white
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H317-H335
  • Precautionary statements P261-P264-P271-P272-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P333+P313-P337+P313-P363-P403+P233-P405-P501

GNE-6640 Chemical Properties,Usage,Production

  • Uses GNE-6640 is a selective and non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP47 and Ub-MDM2, respectively[1][2].
  • References [1] Kategaya L, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26;550(7677):534-538. DOI:10.1038/nature24006
    [2] Tanguturi P, et al. The role of deubiquitinating enzymes in cancer drug resistance. Cancer Chemother Pharmacol. 2020 Apr;85(4):627-639. DOI:10.1007/s00280-020-04046-8
GNE-6640 Preparation Products And Raw materials
Raw materials
Preparation Products
GNE-6640 Suppliers
Global(52)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
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  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
  • Supplier：
    LEAPCHEM CO., LTD.
  • Tel：+86-852-30606658
  • Email：market18@leapchem.com
  • Country：China
  • ProdList：43340
  • Advantage：58
  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
  • ProdList：52924
  • Advantage：58
GNE-6640 Spectrum
2009273-67-8, GNE-6640Related Search:
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  • 抑制剂
  • 中药对照品
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  • 4-(2-氨基-4-乙基-5-(1H-吲唑-5-基)吡啶-3-基)苯酚
  • 2009273-67-8
  • GNE-6640, 10 mM in DMSO
  • 4-(2-Amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl)phenol
  • Deubiquitinase,GNE6640,GNE-6640,DUBs,inhibit,Inhibitor,GNE 6640
  • GNE-6641
  • Phenol, 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridinyl]-
  • GNE-6640;GNE 6640;GNE6640;2009273-67-8
  • CS-2824

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