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gne-131

gne-131 Structure
gne-131
  • CAS No.1629063-81-5
  • Chemical Name:gne-131
  • CBNumber:CB04660411
  • Molecular Formula:C23H30N4O3S
  • Formula Weight:442.57
  • MOL File:1629063-81-5.mol
gne-131 Property
  • Density 1.70±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO : 125 mg/mL (282.44 mM)
  • form Solid
  • pka 4.06±0.30(Predicted)
  • color Light yellow to yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

gne-131 Chemical Properties,Usage,Production

  • Uses GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.
  • in vivo

    GNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain[1].

  • IC 50 Nav1.7: 3 nM (IC50)
  • References [1] Focken T, et al. Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain. J Med Chem. 2018 Jun 14 DOI:10.1021/acs.jmedchem.7b01826
gne-131 Preparation Products And Raw materials
Raw materials
Preparation Products
gne-131 Suppliers
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gne-131 Spectrum
1629063-81-5, gne-131Related Search:
  • 抑制剂
  • 化合物GNE-131,10 MM DMSO 溶液
  • N-(7-(金刚烷-1-基甲氧基)-6-环丙基-[1,2,4]三唑并[4,3-A]吡啶-3-基)环丙烷磺酰胺
  • 化合物GNE-131
  • 1629063-81-5
  • GNE-131, 10 mM in DMSO
  • N-(7-(Adamantan-1-ylmethoxy)-6-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)cyclopropanesulfonamide
  • Na+ channels,inhibit,GNE131,Na channels,Inhibitor,Sodium Channel,GNE-131,GNE 131
  • N-[6-Cyclopropyl-7-(tricyclo[3.3.1.13,7]dec-1-ylmethoxy)-1,2,4-triazolo[4,3-a]pyridin-3-yl]cyclopropanesulfonamide
  • Cyclopropanesulfonamide, N-[6-cyclopropyl-7-(tricyclo[3.3.1.13,7]dec-1-ylmethoxy)-1,2,4-triazolo[4,3-a]pyridin-3-yl]-
  • CS-2887
  • GNE-131;GNE131;GNE 131
  • gne-131

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