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TCPOBOP

TCPOBOP Structure
TCPOBOP
  • CAS No.76150-91-9
  • Chemical Name:TCPOBOP
  • CBNumber:CB8155924
  • Molecular Formula:C16H8Cl4N2O2
  • Formula Weight:402.06
  • MOL File:76150-91-9.mol
TCPOBOP Property
  • Boiling point 444.8±45.0 °C(Predicted)
  • Density 1.518±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO: >10 mg/mL
  • pka -0.52±0.10(Predicted)
  • form solid
  • color white
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
  • FDA UNII P4R368GDD7
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :3
  • RTECS  :UT7145000
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
TCPOBOP Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: T1443
  • Product name : TCPOBOP
  • Purity: ≥98% (HPLC), solid
  • Packaging: 5MG
  • Price: ₹7555.85
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 580563
  • Product name : TCPOBOP - CAS 76150-91-9 - Calbiochem
  • Purity: The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents.
  • Packaging: 25MG
  • Price: ₹22390
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 580563
  • Product name : TCPOBOP - CAS 76150-91-9 - Calbiochem
  • Purity: The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents.
  • Packaging: 25MG
  • Price: ₹22390
  • Updated: 2022/06/14
  • Buy: Buy

TCPOBOP Chemical Properties,Usage,Production

  • Description TCPOBOP (76150-91-9) is an activator of the mouse constitutive androstane receptor (mCAR) and human Preganane X receptor.1 Tumor promoter of mouse hepatocarcinogenesis.
  • Uses TCPOBOP is an agonist for mCAR, inducing cytochrome P450 monooxygenases and multidrug resistance and cenobiotic efflux proteins.
  • General Description A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver.
  • Biochem/physiol Actions TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents.
  • in vivo

    TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours[1].

    Animal Model:METfl/fl: Tam-Cre+/+ mice with a targeted deletion for exon 16 with MET KO[1]
    Dosage:3 mg/kg
    Administration:Oral; 1, 2, 5 days
    Result:Increased Liver weight to body weight.
  • IC 50 Bcl-2
  • References 1) Tzameli et al. (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR; Mol. Cell. Biol., 20 2951 2) Diwan et al. (1992) Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine; Carcinogenesis, 13 1893
TCPOBOP Preparation Products And Raw materials
Raw materials
Preparation Products
TCPOBOP Suppliers
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TCPOBOP Spectrum
76150-91-9, TCPOBOPRelated Search:
  • 抑制剂
  • 合成材料中间体
  • 合成有机化合物配体
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Cell Cycle
  • Cell Cycle Regulators
  • Apoptosis and Cell Cycle
  • C16H8Cl4N2O2
  • C16H8N2O2Cl4
  • 化合物TCPOBOP,10 MM DMSO 溶液
  • TCPOBOP,ANDROSTANE RECEPTOR (MCAR)激动剂
  • TCPBOOP,鼠类本构雄激素受体(MCAR)激动剂
  • 化合物TCPOBOP
  • 1,4-双((3,5-二氯吡啶-2-基)氧基)苯
  • 76150-91-9
  • TCPOBOP, 10 mM in DMSO
  • TCPOBOP, Androstane receptor (mCAR) agonist
  • inhibit,Bcl-2 Family,TCPOBOP,Inhibitor
  • Pyridine, 2,2'-[1,4-phenylenebis(oxy)]bis[3,5-dichloro-
  • 3,5-dichloro-2-{4-[(3,5-dichloropyridin-2-yl)oxy]phenoxy}pyridine
  • 1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene
  • TCPOBOP - CAS 76150-91-9 - Calbiochem
  • 3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzene
  • 2,2'-[Benzene-1,4-diylbis(oxy)]bis(3,5-dichloropyridine)
  • 2,2'-(p-Phenylenebisoxy)bis(3,5-dichloropyridine)
  • 2,2'-(4,1-Phenylenebisoxy)bis(3,5-dichloropyridine)
  • 1,4-Bis[(3,5-dichloropyridin-2-yl)oxy]benzene
  • 1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene
  • 1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene, 3,3μ,5,5μ-Tetrachloro-1,4-bis(pyridyloxy)benzene
  • 2,2’-(1,4-phenylenebis(oxy))bis(3,5-dichloro-pyridin
  • TCPOBOP
  • 1,4-BIS[2-(3,5-DICHLOROPYRIDYLOXY)]BENZENE
  • 3,3',5,5'-TETRACHLORIDE-BPB
  • 3,3',5,5'-TETRACHLORIDE-BISPYRIDYLOXYBENZENE

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