ChemicalBook CAS DataBase List 76150-91-9

76150-91-9

Name	TCPOBOP
CAS	76150-91-9
Molecular Formula	C16H8Cl4N2O2
MDL Number	MFCD00057368
Molecular Weight	402.06
MOL File	76150-91-9.mol

Synonyms

TCPOBOP 3,3',5,5'-TETRACHLORIDE-BPB TCPOBOP - CAS 76150-91-9 - Calbiochem 1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene 1,4-BIS[2-(3,5-DICHLOROPYRIDYLOXY)]BENZENE 1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene 3,3',5,5'-TETRACHLORIDE-BISPYRIDYLOXYBENZENE 1,4-Bis[(3,5-dichloropyridin-2-yl)oxy]benzene 3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzene 2,2'-(p-Phenylenebisoxy)bis(3,5-dichloropyridine) 2,2'-(4,1-Phenylenebisoxy)bis(3,5-dichloropyridine) 2,2’-(1,4-phenylenebis(oxy))bis(3,5-dichloro-pyridin Pyridine, 2,2'-[1,4-phenylenebis(oxy)]bis[3,5-dichloro- 2,2'-[Benzene-1,4-diylbis(oxy)]bis(3,5-dichloropyridine) 3,5-dichloro-2-{4-[(3,5-dichloropyridin-2-yl)oxy]phenoxy}pyridine 1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene, 3,3μ,5,5μ-Tetrachloro-1,4-bis(pyridyloxy)benzene

Chemical Properties

Boiling point	444.8±45.0 °C(Predicted)
density	1.518±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >10 mg/mL
form	solid
pka	-0.52±0.10(Predicted)
color	white
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
InChI	1S/C16H8Cl4N2O2/c17-9-5-13(19)15(21-7-9)23-11-1-2-12(4-3-11)24-16-14(20)6-10(18)8-22-16/h1-8H
InChIKey	BAFKRPOFIYPKBQ-UHFFFAOYSA-N
SMILES	Clc1cnc(Oc2ccc(Oc3ncc(Cl)cc3Cl)cc2)c(Cl)c1

Safety Data

Safety Statements	22-24/25 less more
WGK Germany	3
RTECS	UT7145000
Storage Class	11 - Combustible Solids

Hazard Information

Description

TCPOBOP (76150-91-9) is an activator of the mouse constitutive androstane receptor (mCAR) and human Preganane X receptor.1 Tumor promoter of mouse hepatocarcinogenesis.

Uses

TCPOBOP is an agonist for mCAR, inducing cytochrome P450 monooxygenases and multidrug resistance and cenobiotic efflux proteins.

General Description

A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver.

Biochem/physiol Actions

TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents.

in vivo

TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours^[1].

Animal Model:	MET^fl/fl: Tam-Cre^+/+ mice with a targeted deletion for exon 16 with MET KO^[1]
Dosage:	3 mg/kg
Administration:	Oral; 1, 2, 5 days
Result:	Increased Liver weight to body weight.

IC 50

Bcl-2

References

1) Tzameli et al. (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR; Mol. Cell. Biol., 20 2951 2) Diwan et al. (1992) Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine; Carcinogenesis, 13 1893

Spectrum Detail

Supplier

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Telephone400-6206333 13167063860

Websitehttp://www.aladdin-e.com/

Sigma-Aldrich

Telephone021-61415566 800-8193336

Websitehttps://www.sigmaaldrich.cn

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 13636370518

Websitehttps://www.shyuanye.com

Tianjin Kailiqi Biotechnology Co., Ltd.

Telephone 15076683720

Websitehttp://www.cw-bio.com

Shanghai SuperLan Chemcial Technique Centre

Telephone0-2022843681 15618226720

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList19886/0_EN.htm

Jiangsu aikang biomedical research and development co., LTD

Telephone025-58859352 17714375163

Websitehttp://www.aikonchem.com/

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Telephone 18818260767

Websitehttp://www.chemegen.com

Henan Weitesi Chemical Technology Co. LTD

Telephone0371-55135753 18003832934

Website

Energy Chemical

Telephone021-58432009 400-005-6266

Websitehttp://www.energy-chemical.com

Jinan Jiuli Biotechnology Co. , Ltd.

Telephone 15865264761

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm

Beijing Jin Ming Biotechnology Co., Ltd.

Telephone010-60605840

Websitehttp://www.jm-bio.com/

Kaifeng Mingren Pharmaceutical Co.,LTD

Telephone0371-65741762

Websitehttps://www.kfmryy.com/

InvivoChem

Telephone 13549236410

Websitehttps://www.invivochem.cn/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Shanghai Yingxin laboratory equipment Co., Ltd

Telephone021-021-59178156 15300768757

Websitehttp://www.yingxinbio.com/

Shanghai Guchen Biotechnology Co., LTD

Telephone021-34675735 19147740836

Websitehttp://www.shgcsw-edu.com

Beijing Solarbio Science & Tecnology Co., Ltd.

Telephone010-50973130 17801761073

Websitehttps://www.solarbio.com/

1of4

Related Products

Send Inquriy